… in cancer metastasis. Furthermore, we discuss the potential use of EVs in clinical treatment of
metastasis. … , we use the term EVs for all types of vesicles present in the extracellular space. …

… A major breakthrough in our understanding of the generation of predetermined metastatic
microenvironments, referred to as pre-metastatic niches 24,109 , arose from the pivotal …

… Tumor-secreted extracellular vesicles (EVs) are critical … primary tumor growth and metastatic
evolution. EVs orchestrate … pre-metastatic niche formation and subsequent metastasis. …

… TME that contribute to cancer metastasis by modulating of EVs release from cancer cells [29]…
influence cancer metastasis by modulating proliferation, protrusion, invasion of cancer cells, …

Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are
released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids, and …

… the role of cancer-derived EVs in cancer metastasis has been … cancer metastasis by relying
on a balanced perspective that looks at challenges faced previously by extracellular vesicle …

… , cancer–niche coevolution, immunomodulation, and establishment of premetastatic niche,
all of which are important to the process of metastasis… and after cancer metastasis, paving the …

… The development of cancer metastases at distant organs requires disseminated tumor cells'
… the metastatic sites. Stromal cells in the tumor microenvironment regulate cancer progression…

… question: If these cancer-derived vesicles are in circulation, … mechanism against extracellular
vesicle incorporation/ “… of the pre-metastatic niche, and increased cancer-related death. We …

… For example, the miR-200 family, which regulates mesenchymal-epithelial transition (MET)
(28), was secreted in EVs from metastatic breast cancer lines to nonmetastatic cancer cells, …