… This chapter reviews the roles of the ECM, integrins, and focal adhesion signaling in cyst …
The formation of focal adhesions is accompanied by the recruitment of focal adhesion kinase (…

… novel, druggable targets for proteinuric kidney diseases. Here we review … kidney diseases
beneficially and directly target the podocyte actin cytoskeleton associated with focal adhesions …

… of focal adhesion abnormalities in ARPKD. Alterations in adhesion-dependent focal adhesion
… age-matched normal human kidneys were correlated with specific abnormalities in the site-…

… kidneys, where it is predominantly seen in focal adhesions of the epithelial basal
membranes adjacent to the extracellular matrix. After birth, polycystin-1 is down-regulated in …

… Polycystic kidney disease is the most common heritable disease in humans. In addition to …
dominant polycystic kidney disease (ADPKD), the most common heritable human disease [1]. …

… polycystic kidney disease (ADPKD) is a typically monogenetic hereditary kidney disease …
Innumerous fluid-filled and consistently enlarging cysts in bilateral kidneys lead to renal …

… Although mutations in the integrin α3 subunit that cause human kidney disease were …
α3β1 from focal adhesions into tetraspanin webs, allowing for tight adhesion of podocytes to …

… required for podocytes at the kidney filtration barrier. Finally, … disease, and therefore offers
unexpected interventional therapeutic strategies to prevent podocyte loss and kidney disease …

… protein clustering, formation of focal adhesion complexes by binding of … Intracelluar signaling
is mediated via focal adhesion … -1 have been detected in focal adhesion complexes and are …

… adhesion receptors, including integrins and focal adhesion proteins. Integrins are αβ
heterodimeric cell adhesion receptors, while focal adhesions … integrins and focal adhesion …