… Magnetic resonance imaging using hyperpolarized gases is emerging as a technical
challenge and … Obviously, their physiologic concentrations in vivo are too small, and even after …

… their strengths and the challenges that remain to translate … MRI might be used in the future
to gain more insight into gas … of MRI, both of which represent fundamental challenges that …

… First, in order to evaluate both methods over a large physiological range of data, we …
challenges, we investigated the response to four different mixtures of O 2 and CO 2 breathing gases. …

… and perfusion, and multinuclear MRI provides further insight into gas exchange; this can help
… physiological motion caused by respiration and the heart present challenges for lung MRI. …

… the 1990s, the development of functional lung MRI has taken flight through the … gases has
paved the way for pulmonary assessment using MRI, and has resulted in novel physiological …

… gas-exchange abnormalities is challenging, because no methods currently exist to directly
image the gas … the tissue barrier spaces and RBCs in the gas exchange regions of the lung. …

… challenge, the change in BOLD or ASL signal during gas … Physiological MRI during
hypercapnia thus assesses whether … Assumed iso-metabolism during gas challenges is debated …

… Increased oxygen content of the arterial blood accompanying hyperoxic gas breathing may
… assess tumor physiological responses to oxygen challenge using quantitative diffusion MRI, …

… studies of brain during various cerebral vasomotor challenges have … The physiological
response of vasomotor tone to … Although it is not practical to perform blood gas measurements …

… The gas perturbations are assumed to be physiologically … (QUO2) MRI, 99,100 involves the
use of three gases to produce … maps of control subjects using gas-challenge calibrated fMRI. (…