… Mechanisms by which DNA methylation inhibits gene transcription. (A) … allows transcription
factors to bind and transcription to occur. (B) Methylation of CpGs inhibits transcription factor …

… in animal cell DNA was noted over 40 years ago, its role in the regulation of gene activity
has … The first indications that DNA methylation patterns of particular genes may indeed be …

… , such methylation corresponds to the inactive state of the gene … to account for transcriptional
repression by DNA methylation, and … with the binding of specific transcription factors to their …

… between DNA methylation, chromatin structure, and gene … association between DNA
methylation and expression than … about the role of DNA methylation in controlling gene …

… Although we focus on molecular mechanisms that might influence DNA methylation and
gene expression in dividing cells, DNA demethylation is also important in nondividing terminally …

… In this review, we will discuss the basic function of DNA methylation in epigenetic gene
regulation, and further highlight its role in neural development and neurological disease. …

… and initiating transcription. However, not all transcription factors are sensitive to DNA methylation
… Therefore, it cannot be the only mechanism by which DNA methylation regulates gene …

… To test whether DNA methylation inhibits gene transcription in vivo , we used the IE to
artificially undermethylate a tissue-specific promoter region and examined expression of a reporter…

… DNA methylation is associated with the silencing of gene expression. The predominant
mechanism involves the methylation of DNA … that preferentially recognize methylated DNA. In turn…

… in neighboring genes while leaving transposons silent. Thus, by balancing both repressive
and activating transcriptional effects, DNA methylation can act to fine-tune gene expression. …