DNA methylation and the regulation of gene transcription
JT Attwood, RL Yung, BC Richardson - Cellular and Molecular Life …, 2002 - Springer
… Mechanisms by which DNA methylation inhibits gene transcription. (A) … allows transcription
factors to bind and transcription to occur. (B) Methylation of CpGs inhibits transcription factor …
factors to bind and transcription to occur. (B) Methylation of CpGs inhibits transcription factor …
DNA methylation and gene expression
A Razin, H Cedar - Microbiological reviews, 1991 - Am Soc Microbiol
… in animal cell DNA was noted over 40 years ago, its role in the regulation of gene activity
has … The first indications that DNA methylation patterns of particular genes may indeed be …
has … The first indications that DNA methylation patterns of particular genes may indeed be …
DNA methylation
R Singal, GD Ginder - Blood, The Journal of the American …, 1999 - ashpublications.org
… , such methylation corresponds to the inactive state of the gene … to account for transcriptional
repression by DNA methylation, and … with the binding of specific transcription factors to their …
repression by DNA methylation, and … with the binding of specific transcription factors to their …
DNA methylation and gene expression
Z Siegfried, I Simon - Wiley Interdisciplinary Reviews: Systems …, 2010 - Wiley Online Library
… between DNA methylation, chromatin structure, and gene … association between DNA
methylation and expression than … about the role of DNA methylation in controlling gene …
methylation and expression than … about the role of DNA methylation in controlling gene …
How does DNA methylation repress transcription?
… Although we focus on molecular mechanisms that might influence DNA methylation and
gene expression in dividing cells, DNA demethylation is also important in nondividing terminally …
gene expression in dividing cells, DNA demethylation is also important in nondividing terminally …
[HTML][HTML] DNA methylation and its basic function
LD Moore, T Le, G Fan - Neuropsychopharmacology, 2013 - nature.com
… In this review, we will discuss the basic function of DNA methylation in epigenetic gene
regulation, and further highlight its role in neural development and neurological disease. …
regulation, and further highlight its role in neural development and neurological disease. …
The role of DNA methylation in gene regulation
PA Bommarito, RC Fry - Toxicoepigenetics, 2019 - Elsevier
… and initiating transcription. However, not all transcription factors are sensitive to DNA methylation
… Therefore, it cannot be the only mechanism by which DNA methylation regulates gene …
… Therefore, it cannot be the only mechanism by which DNA methylation regulates gene …
DNA methylation represses transcription in vivo
Z Siegfried, S Eden, M Mendelsohn, X Feng… - Nature …, 1999 - nature.com
… To test whether DNA methylation inhibits gene transcription in vivo , we used the IE to
artificially undermethylate a tissue-specific promoter region and examined expression of a reporter…
artificially undermethylate a tissue-specific promoter region and examined expression of a reporter…
DNA methylation and silencing of gene expression
J Newell-Price, AJL Clark, P King - Trends in Endocrinology & Metabolism, 2000 - cell.com
… DNA methylation is associated with the silencing of gene expression. The predominant
mechanism involves the methylation of DNA … that preferentially recognize methylated DNA. In turn…
mechanism involves the methylation of DNA … that preferentially recognize methylated DNA. In turn…
A DNA methylation reader complex that enhances gene transcription
… in neighboring genes while leaving transposons silent. Thus, by balancing both repressive
and activating transcriptional effects, DNA methylation can act to fine-tune gene expression. …
and activating transcriptional effects, DNA methylation can act to fine-tune gene expression. …
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