… to interpret how genetic variants alter gene regulation. We do not know how to “read the
genome” and predict gene regulatory outputs. Our understanding of regulatory mechanisms and …

… genetic variation influences gene expression, focusing upon inter-individual variation in gene
… they are designed to tell us about genetic variation, and what are their limitations from both …

… to or act in gene regulation. We show that unlike genetic regulatory variation, DNA methylation
… Finally, inferred mechanistic relationships using genetic variation as well as correlations …

… The candidate gene approach has been widely used to analyse possible associations
between genetic variants and disease outcome, with selection of genes based on a priori …

… to adaptive evolution of regulatory compared with structural genetic variation has diminished,
despite the discovery of examples of interspecies variation in gene expression level …

… and distant genetic variation on the dynamics of gene expression throughout an extensive
time period. Moreover, the approach developed here should facilitate the genetic dissection of …

… In conclusion, genetic variants affecting gene expression and DNA methylation levels
often overlaps with functional genomic elements. This also indicates that the DNA sequence …

… by which genetic variants can mediate tissue-dependent gene expression. We observed
that the genetic variants that associated with complex traits are more likely to affect gene …

… Selection involving such non-coding DNA sequences important to gene regulation is … We
have recently shown how genetic variation defines a functional VDRE in the proximal promoter …

… An important question concerning the genetic basis and evolution of complex traits is the
relative contribution of gene regulation versus protein structure. If gene-expression differences …