… methylation in cancer beyond the fact that DNA methylation … of methylation changes, particularly
de novo methylation in the … to whether these common methylation defects contribute on a …

… This chapter aims to review the major influences of DNA methylation on … the genomic
instability triggered by epigenetic changes with a specific emphasis on the role of DNA methylation. …

… are irradiated which establish a heritable phenotype of genomic instability (radiation-induced
genomic instability: RIGI). The manifestation of this instability may be delayed for many cell …

… These observations include; (1) aberrant DNA methylation patterns cause genome instability
like mitotic catastrophe in cell lines [63,64]; (2) mice lacking Dnmt1 are genetically unstable …

… We specifically focus on the controversies related to genomic instability and DNA
methylation, and present a model, which interrelates these phenomena to the basic evolutionary …

… mechanism of how DNA methylation acts within the … DNA methylation. Ablation of Dnmt1
causes an acute phenotype characterized by global DNA hypomethylation, genome instability, …

… promoter methylation studies of the DNA methylation … genome instability that tracked
temporally with reduced chromosomal methylation which recovered over time, reduced genome …

… silencing of MLH1 and CDKN2A and the key tumour suppressors BRCA1, p53 and RB1
represent a paradigmatic association between DNA methylation and cancer genome instability. …

… role of genomic hypomethylation in the generation of genomic instability (GI) and tumorigenesis,
but whether DNA … We investigated the correlation between GI and DNA methylation, and …

… of DNA methylation, DNA … DNA damage, altered DNA methylation and dysregulated BORIS
expression in the exposed testes. Furthermore, we show that cranial irradiation caused DNA …