Genome-wide screening for understanding the role of DNA methylation in colorectal cancer

F Sipos, G Mũzes, AV Patai, I Fũri, B Péterfia… - …, 2013 - Taylor & Francis
… Supposedly, genome-wide DNA methylation screening will be used to determine disease-specific
and disease stage-specific methylated DNA sequences that can be further specified …

Diagnostic utility of genome-wide DNA methylation testing in genetically unsolved individuals with suspected hereditary conditions

E Aref-Eshghi, EG Bend, S Colaiacovo… - The American Journal of …, 2019 - cell.com
… In the present study, using genome-wide DNA methylation analysis, we develop a computational
model for the concurrent identification of 14 ND/CA syndromes currently known to be …

Profiling genome-wide DNA methylation

WS Yong, FM Hsu, PY Chen - Epigenetics & chromatin, 2016 - Springer
… relies on both computational power for genome-wide screening and statistical testing. In
Table 2, we included tools for implementing statistical methods in DMR screening [110, 112–115…

Genome-Wide Dna Methylation Profiling Using Infinium® Assay

M Bibikova, J Le, B Barnes, S Saedinia-Melnyk… - …, 2009 - Taylor & Francis
… Moreover, tissue-specific methylation (variation in methylation … a genome-wide scalable
array-based methylation readout … , the Infinium Methylation assay is an ideal screening tool …

Clinical epigenomics: genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders

B Sadikovic, MA Levy, J Kerkhof, E Aref-Eshghi… - Genetics in …, 2021 - nature.com
… This paper describes the implementation of genome-wide DNA methylation analysis in
clinical testing of individuals with rare genetic disorders. It represents a major milestone in …

methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

A Akalin, M Kormaksson, S Li, FE Garrett-Bakelman… - Genome biology, 2012 - Springer
… Following the differential methylation test and calculation of P-values, methylKitwill use the
… [31], which corrects for the problem of multiple hypothesis testing [32, 33]. However, we also …

Genome-wide screening of genes regulated by DNA methylation in colon cancer development

S Spisak, A Kalmár, O Galamb, B Wichmann, F Sipos… - 2012 - journals.plos.org
… was further studied to verify the extent of DNA methylation and its effect on the protein level.
… for genome-wide screening of genes which are regulated or inactivated by DNA methylation. …

Quantitative comparison of genome-wide DNA methylation mapping technologies

C Bock, EM Tomazou, AB Brinkman, F Müller… - Nature …, 2010 - nature.com
… In the current study, we explored two complementary approaches to test for repeat-associated
DNA methylation differences. First, we included repetitive regions alongside nonrepetitive …

Genome-wide analysis of DNA methylation identifies two CpG sites for the early screening of colorectal cancer

X Wang, D Wang, H Zhang, M Feng, X Wu - Epigenomics, 2020 - Taylor & Francis
… similar genome-wide DNA methylation patterns, confirming that aberrant DNA methylation
occurs … Genome-wide DNA methylation analysis identifies candidate epigenetic markers and …

Genome-wide screening of DNA methylation in bovine blastocysts with different kinetics of development

J Ispada, CB De Lima, MA Sirard, PK Fontes… - Epigenetics & …, 2018 - Springer
… As gene expression is regulated by epigenetic factors, and that includes DNA methylation
patterns, in this study we compared the global DNA methylation profile of embryos with …