… ethanol exposure were targeted by multiple dysregulated transcription factors, these factors
could produce synergistic ethanol dysregulation effects during early zebrafish development. …

… It is widely believed that genomes are transcriptionally inactive from fertilization until zygotic
genome activation (ZGA). Thus, the earliest genes expressed probably support the rapid cell …

In developmental toxicity, the evaluation of early biomarkers may be predictive of later
developmental outcomes. Over the last few years, new models have been proposed for predicting …

… Of these, the alteration of DNA methylation patterns and subsequent reprogramming of
developmental … In early zebrafish development, angiogenesis occurs in two surges to form the …

… post-transcriptional RNA methylation as a new … methylated maternal transcripts in the
absence of functional Ythdf2 may lead to the observed defects during early zebrafish development. …

… higher than that of any other gene during early zebrafish development [19]. This suggests
that … and Nanog to open up distal regions that are DNA methylated [26], we find that Pou5f3, …

… dynamics during early zebrafish development, highlighting … of DNA methylation on the
maternal genome during early … virtually all regions lacking DNA methylation, and perturbation of …

… and transcriptional changes throughout early zebrafish development. These data provide …
which were strongly affected by loss of DNA methylation, and rDNA, which was altered by …

… Indeed, given the importance of Wnts during early zebrafish development a tight regulation
can be expected. The close relationship between the pathway and its regulators is also …

… However, the functions of myc genes in early zebrafish development are poorly understood.
The recently identified mych gene has been linked to cell survival and neural crest …