In vivo epigenomic profiling of germ cells reveals germ cell molecular signatures

JH Ng, V Kumar, M Muratani, P Kraus, JC Yeo… - Developmental cell, 2013 - cell.com
embryonic stem, and germ cells revealed promoters and enhancers needed for stem cell
maintenance and germ cellgerm cell cis-regulatory regions, and our results implicate Nr5a2 in …

Mitochondrial morphology in human fetal and adult female germ cells

PM Motta, SA Nottola, S Makabe, R Heyn - Human reproduction, 2000 - academic.oup.com
… The germinal component of the gonads (including the ovaries) originates from a small
number of primordial germ cells fPGCs) that are firstly detected in human embryos at the third …

The problem of the origin of germ cells

F Heys - The Quarterly Review of Biology, 1931 - journals.uchicago.edu
germ cells in man. Thus it is admitted by many that the so-called primordial germ cells do
appear in early embryonic … From there they migrate to the genital ridge, such cells being the pre…

Generation of germ cells from pluripotent stem cells in mammals

M Hayashi, T Kawaguchi… - … medicine and biology, 2018 - Wiley Online Library
… The germ cell lineage transmits genetic and epigenetic information to the next generation.
Primordial germ cells (PGCs), the early embryonic precursors of sperm or eggs, have been …

Germ cell specification in mice

M Saitou - Current opinion in genetics & development, 2009 - Elsevier
… In mice, germ cell fate is induced in a subset of pluripotent … cells during early gastrulation.
Reflecting the function of the germ line as the transducer of genetic information, germ cell

Commitment of fetal male germ cells to spermatogonial stem cells during mouse embryonic development

H Ohta, T Wakayama, Y Nishimune - Biology of reproduction, 2004 - academic.oup.com
cell activity of fetal germ cells in more detail, we transplanted fetal germ cells along with
infant germ cells labeled with GFP and compared their stem cell activities by differentially …

Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila

LA Moore, HT Broihier, MV Doren, LB Lunsford… - …, 1998 - journals.biologists.com
… mutants demonstrates that germ cell migration can be … germ cells to form the embryonic
gonad. Moreover, mutations that we isolated affecting embryonic patterning as well as germ cell

Turning germ cells into stem cells

PJ Donovan, MP de Miguel - Current opinion in genetics & development, 2003 - Elsevier
… to embryonal carcinoma cells, the pluripotent stem cells of … embryonic germ cells, pluripotent
stem cells that can contribute to all the lineages of chimeric embryos including the germline. …

Early germ cell segregation and distribution in the quail blastodisc

L Pardanaud, C Buck, F Dieterlen-Lièvre - Cell differentiation, 1987 - Elsevier
… for cells that we suspected to be primordi~ germ cells. Here we show that these cells are
indeed PGCs, and we repo~ a det~led quantitative ~udy of thor spatifl di~ribufion in the early

Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila …

G Seydoux, MA Dunn - Development, 1997 - journals.biologists.com
… in early embryonic germ cells. mAb H5 failed to stain germ cells entirely in both C. elegans
and Drosophila pregastrulation embryos. With mAb H14, some staining could be detected in …