Epigenetic germline mosaicism in infertile men

S Laurentino, J Beygo, V Nordhoff… - Human molecular …, 2015 - academic.oup.com
infertility (10). In recent years, epigenetic factors in sperm have been indicated as potentially
linked to male infertility (11… epigenetic defects found in some infertile men are due to random …

Familiarity, recessivity and germline mosaicism

JH Edwards - Annals of human genetics, 1989 - Wiley Online Library
… arising in the male are unlikely to lead to manifest germline mosaicism. However, the …
germline mosaicism in children fathered by pubertal males of about &. As the peak male fertility is …

Sperm mosaicism: implications for genomic diversity and disease

MW Breuss, X Yang, JG Gleeson - Trends in Genetics, 2021 - cell.com
… While sperm mosaicism has few consequences for men, the offspring and future generations
are unwitting recipients of gonadal cell mutations, often yielding severe disease. Recent …

[PDF][PDF] Frequency of somatic and germ-line mosaicism in retinoblastoma: implications for genetic counseling

KC Sippel, RE Fraioli, GD Smith, ME Schalkoff… - The American Journal of …, 1998 - cell.com
… out germ-line mosaicism; in this situation, mosaicism would be recognized only if the mosaic
… Whenever possible (eg, in male mosaics), it is best to base the recurrence risk estimate on …

A rare cause of male infertility: 45, X/46, XY mosaicism

EC Akinsal, N Baydilli, R Bayramov… - Urologia …, 2018 - karger.com
… of 8 infertile male cases with the 45,X/46,XY karyotype who were admitted to our infertility
clinic. Materials and Methods: The records of cases who were admitted to our infertility clinic …

Male factor infertility impacts the rate of mosaic blastocysts in cycles of preimplantation genetic testing for aneuploidy

N Tarozzi, M Nadalini, C Lagalla, G Coticchio… - Journal of Assisted …, 2019 - Springer
… This relationship does not appear to impact the rate of aneuploid blastocysts, suggesting
that chromosome segregation in the male germline during meiosis is unaffected by factors that …

Evaluation for germline mosaicism in sperm donors following diagnosis of dominant disorders in donor-conceived offspring

K Baldwin, P Callum - Fertility and Sterility, 2019 - fertstert.org
… While the cases investigated in this study did not identify any evidence of gonadal mosaicism,
routine evaluation of DNA from sperm cells may help to identify mosaicism and mitigate …

Should non-mosaic Klinefelter syndrome men be labelled as infertile in 2009?

G Fullerton, M Hamilton, A Maheshwari - Human reproduction, 2010 - academic.oup.com
… We included studies that involved mosaic Klinefelter syndrome men only if we were able to
extract the data exclusive to non-mosaic patients. Case series were included but case reports …

[HTML][HTML] Sperm chromosome analysis and outcome of IVF in patients with non-mosaic Klinefelter's syndrome

J Levron, A Aviram-Goldring, I Madgar, G Raviv… - Fertility and sterility, 2000 - Elsevier
… found in other severe male factor infertility patient groups. … infertile males undergoing ICSI
as compared to fertile donors (16). In other study we demonstrated a linkage between gonadal

Somatic/gonadal mosaicism for structural autosomal rearrangements: female predominance among carriers of gonadal mosaicism for unbalanced rearrangements

NV Kovaleva, PD Cotter - Molecular Cytogenetics, 2016 - Springer
… failure, only one was a male with infertility, and one was a … Among 30,376 infertile patients
three carriers of mosaicism for … of mosaicism for an unbalanced Rea (N/del, mosaicism for …