… inhibitors of DNA methylation in the … DNA methylation in γ-globin gene regulation, describe
clinical trials with agents that hypomethylate DNA and speculate about the future role of DNA …

… inducer of FL cell differentiation it inhibits methylation of DNA and tRNA in vivo but does
not … of globin synthesis in FL cells, we examined the degree of hypomethylation of DNA and …

… Here we show that total DNA methylation of the human y-globin gene region prevents globin
… similar experiment with the human Cal-globin gene (Busslinger and Flavell, 1983). Hence, …

… Using a genetic approach in transgenic mice we demonstrate that DNA methylation plays
a local role in preventing the activation of γ globin in adult erythroid cells, and this effect is …

… In the present study, we have used peripheral blood normoblasts to analyze the degree
of DNA methylation along the β-globin gene cluster. Mature orthochromatic normoblasts are …

… of DNA hypomethylation occur in the human β-globin locus, we have evaluated DNA methylation
… and in cells expressing embryonic globin genes derived from human embryonic stem (…

… globin genes are a suitable system for studying the correlation of gene expression with
DNA methylation. Genes expressed in the fetal (Gy, Ay) and adult (6, p) phases of human …

… DNA methylation in the y-&-1-globin gene cluster was … Restriction enzymes insensitive to
the state of DNA methylation (… sites whose cleavage is sensitive to DNA methylation (Hpa II, …

… cor relation exhibited by DNA methylation at these posi tions and 7-globin gene expression.
Thus, we propose that the transcriptional status of the gene dictates the methylation status of …

… We have investigated the pattern of DNA methylation within the human E, y, S(3 globin
gene region in .90% pure erythroblasts from yolk sacs (YSs), FLs, and AMs. The …