Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study

M Böhm, J Borer, I Ford, JR Gonzalez-Juanatey… - Clinical Research in …, 2013 - Springer
effect of ivabradine on outcomes in heart failure (HF) patients on recommended background
therapies with heart … the EMEA for approval for the use of ivabradine in chronic heart failure. …

Effect of ivabradine on recurrent hospitalization for worsening heart failure in patients with chronic systolic heart failure: the SHIFT Study

JS Borer, M Böhm, I Ford, M Komajda… - European heart …, 2012 - academic.oup.com
… a heart rate of ≥75 bpm (4150 patients in the whole study). In addition, we explored the effect
of ivabradine … The effect of ivabradine on repeated hospitalizations for worsening HF was …

Effect of ivabradine in patients with heart failure with preserved ejection fraction: the EDIFY randomized placebo‐controlled trial

, … chronic heart Failure with ivabradine … - … of Heart Failure, 2017 - Wiley Online Library
… In HFpEF animal models, ivabradine was shown to reduce cardiac fibrosis8 and improve …
chronic heart Failure with ivabradine studY), we studied whether HR reduction with ivabradine

Physiological effects of ivabradine in heart failure and beyond

AN Iness, KM Shah, RC Kukreja - Molecular and Cellular Biochemistry, 2023 - Springer
… Alternative effects of ivabradine include modulation of the renin-angiotensin-aldosterone …
use of ivabradine and explore opportunities for leveraging its potential pleiotropic effects in …

Ivabradine for treatment of heart failure

EA Bocchi, VMC Salemi - Expert opinion on drug safety, 2019 - Taylor & Francis
… common side effects with ivabradine are … Effect of ivabradine in patients with heart failure
with preserved ejection fraction: the EDIFY randomized placebo-controlled trial. Eur J Heart Fail…

The effect of ivabradine therapy on heart failure patients with reduced ejection fraction: a systematic review and meta-analysis

C Hartmann, NL Bosch, L de Aragão Miguita… - International journal of …, 2018 - Springer
effect apart from beta-blockers is not clear. Aim of the review To study the additional effect of
ivabradine, apart from the effect … hospitalization due to HF and heart rate in HFrEF population…

Ivabradine: current and future treatment of heart failure

L Thorup, U Simonsen, D Grimm… - Basic & clinical …, 2017 - Wiley Online Library
… if the patient is severely affected, ivabradine or a combination of AT1 … ivabradine and
investigate the hypothesis that ivabradine may be a first choice of therapy when the resting heart

Effects of ivabradine therapy on heart failure biomarkers

S Ordu, BS Yildiz, YI Alihanoglu, A Ozsoy… - Cardiology …, 2015 - journals.viamedica.pl
… significantly lower in the ivabradine than in the non-ivabradine group (ivabradine: p = 0.004,
… and at 6 months when ivabradine and non-ivabradine groups were compared (baseline: p = …

Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure

GM De Ferrari, A Mazzuero, L Agnesina… - … of Heart Failure, 2008 - Wiley Online Library
… Its potential utility in patients with stable ischaemic heart … However, limited data are available
on the effects of ivabradine in … of ivabradine in patients with advanced heart failure and …

Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study

K Swedberg, M Komajda, M Böhm, JS Borer, I Ford… - The Lancet, 2010 - thelancet.com
… Our results support the importance of heart-rate reduction with ivabradine for improvement
of clinical outcomes in heart failure and confirm the important role of heart rate in the …