Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study
M Böhm, J Borer, I Ford, JR Gonzalez-Juanatey… - Clinical Research in …, 2013 - Springer
… the effect of ivabradine on outcomes in heart failure (HF) patients on recommended background
therapies with heart rates … for approval for the use of ivabradine in chronic heart failure. …
therapies with heart rates … for approval for the use of ivabradine in chronic heart failure. …
Pharmacokinetic‐pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers
I Ragueneau, C Laveille, R Jochemsen… - Clinical …, 1998 - Wiley Online Library
… The effects of ivabradine on heart rate were studied at … ivabradine and S-18982 plasma
levels were determined simultaneously. Results: The maximal reductions of exercise heart rate …
levels were determined simultaneously. Results: The maximal reductions of exercise heart rate …
Anti-ischaemic effect of ivabradine
R Ferrari, A Cargnoni, C Ceconi - Pharmacological research, 2006 - Elsevier
… This cardioprotection is dependent on ivabradine's heart rate-… by heart rate reduction
has been tested for ivabradine and … Ivabradine and atenolol reduced heart rate to the same …
has been tested for ivabradine and … Ivabradine and atenolol reduced heart rate to the same …
Characterization of the heart rate-lowering action of ivabradine, a selective If current inhibitor
JS Borer, JY Le Heuzey - American journal of therapeutics, 2008 - journals.lww.com
… of ivabradine and to describe the relation of its heart rate-lowering action to its clinical effects,
based … as part of the ivabradine development program as submitted to regulatory agencies. …
based … as part of the ivabradine development program as submitted to regulatory agencies. …
Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure☆
GM De Ferrari, A Mazzuero, L Agnesina… - … Journal of Heart …, 2008 - Wiley Online Library
… These findings support the safety of heart rate lowering, and of ivabradine in achieving this
effect, in … role for ivabradine in treatment of patients with moderate and advanced heart failure. …
effect, in … role for ivabradine in treatment of patients with moderate and advanced heart failure. …
Ivabradine in chronic stable angina: effects by and beyond heart rate reduction
… Ivabradine reduces heart rate by inhibiting the I f current of sinoatrial-node … effects of
ivabradine on coronary blood flow and ventricular function in patients with chronic ischemic heart …
ivabradine on coronary blood flow and ventricular function in patients with chronic ischemic heart …
Comparative effects of ivabradine, a selective heart rate‐lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise
R Joannides, N Moore, M Iacob… - British journal of …, 2006 - Wiley Online Library
… the haemodynamic and neurohumoral effects of ivabradine in healthy volunteers, at rest,
during orthostatic tilt tests and during exercise, and to compare these effects with a reference β-…
during orthostatic tilt tests and during exercise, and to compare these effects with a reference β-…
Anti-ischemic effects of ivabradine, a selective heart rate-reducing agent, in exercise-induced myocardial ischemia in pigs
JP Vilaine, JP Bidouard, L Lesage… - Journal of …, 2003 - journals.lww.com
… In the present study, ivabradine and propranolol reduced heart rate recorded during exercise
by similar amounts, but propranolol additionally reduced myocardial contractility. It might …
by similar amounts, but propranolol additionally reduced myocardial contractility. It might …
Effects of ivabradine in patients with stable angina receiving beta-blockers according to baseline heart rate: an analysis of the ASSOCIATE study
JC Tardif, P Ponikowski, T Kahan… - International journal of …, 2013 - Elsevier
… of the resting heart rate at baseline (≤ 65 … heart rate group, we analyzed the effect of
ivabradine versus placebo on resting heart rate and heart rate during exercise, expressed as heart …
ivabradine versus placebo on resting heart rate and heart rate during exercise, expressed as heart …
[HTML][HTML] The effect of ivabradine on the heart rate and sympathovagal balance in postural tachycardia syndrome patients
M Barzilai, G Jacob - Rambam Maimonides Medical Journal, 2015 - ncbi.nlm.nih.gov
… Ivabradine is a selective I f … ivabradine may be an ideal medication for treating POTS
patients. This report provides the results of an investigation in which we studied ivabradine’s effect …
patients. This report provides the results of an investigation in which we studied ivabradine’s effect …
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