… DNMT functions in the context of hematological malignancies. A deeper understanding of
specific targets of DNMTs and the antitumor mechanisms of DNMT … hematological malignancies…

A variety of epigenetic changes contribute to transcriptional dysregulation in myelodysplastic
syndromes (MDSs) and acute myeloid leukemia (AML). DNA methyltransferase (DNMT) …

… of DNA methylation in hematological malignancies described in the current literature. We
discuss in detail the dual role of DNA … DNA methylation patterns in hematological malignancies, …

… hypomethylation, by forming a covalent complex with the major DNA methyltransferase (now
termed DNMT1). DNA methyltransferases catalyze the transfer of a methyl-group from the …

… sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal
domain of the mammalian enzymes is related to bacterial restriction methyltransferases. …

… The success of DNA methyltransferase and histone deacetylase inhibitors represents a …
the epigenome in the treatment of hematological malignancies. Nevertheless, the molecular …

… of DNA methylation abnormalities in hematologic malignancies … catalyzed by various DNA
methyltransferase (DNMT) enzymes. … methyltransferase, acts at the replication fork during DNA …

… In eukaryotes, the catalytic activity of a family of enzymes known as DNA methyltransferases
(DNMTs) results in the addition of a methyl group to the five-carbon position of cytosine …

… Finally, reactivation of tumor-suppressor gene expression through pharmacologic inhibition
of DNA methyltransferase and resultant DNA demethylation appears to be a promising new …

… of DNA methylation and histone methylation, and acetylation in hematologic malignancies.
… and long noncoding RNAs on hematologic malignancies. Furthermore, the implication of …