DNA methyltransferases in hematological malignancies
… DNMT functions in the context of hematological malignancies. A deeper understanding of
specific targets of DNMTs and the antitumor mechanisms of DNMT … hematological malignancies…
specific targets of DNMTs and the antitumor mechanisms of DNMT … hematological malignancies…
Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies
SD Gore - Nature clinical practice Oncology, 2005 - nature.com
A variety of epigenetic changes contribute to transcriptional dysregulation in myelodysplastic
syndromes (MDSs) and acute myeloid leukemia (AML). DNA methyltransferase (DNMT) …
syndromes (MDSs) and acute myeloid leukemia (AML). DNA methyltransferase (DNMT) …
The DNA methylation landscape of hematological malignancies: an update
P Blecua, L Martinez‐Verbo, M Esteller - Molecular Oncology, 2020 - Wiley Online Library
… of DNA methylation in hematological malignancies described in the current literature. We
discuss in detail the dual role of DNA … DNA methylation patterns in hematological malignancies, …
discuss in detail the dual role of DNA … DNA methylation patterns in hematological malignancies, …
Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS
… hypomethylation, by forming a covalent complex with the major DNA methyltransferase (now
termed DNMT1). DNA methyltransferases catalyze the transfer of a methyl-group from the …
termed DNMT1). DNA methyltransferases catalyze the transfer of a methyl-group from the …
The impact of DNA methylation in hematopoietic malignancies
… sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal
domain of the mammalian enzymes is related to bacterial restriction methyltransferases. …
domain of the mammalian enzymes is related to bacterial restriction methyltransferases. …
Epigenetic therapy of hematological malignancies: where are we now?
R Popovic, MY Shah, JD Licht - … advances in hematology, 2013 - journals.sagepub.com
… The success of DNA methyltransferase and histone deacetylase inhibitors represents a …
the epigenome in the treatment of hematological malignancies. Nevertheless, the molecular …
the epigenome in the treatment of hematological malignancies. Nevertheless, the molecular …
Alterations of DNA methylation in hematologic malignancies
LJ Rush, C Plass - Cancer letters, 2002 - Elsevier
… of DNA methylation abnormalities in hematologic malignancies … catalyzed by various DNA
methyltransferase (DNMT) enzymes. … methyltransferase, acts at the replication fork during DNA …
methyltransferase (DNMT) enzymes. … methyltransferase, acts at the replication fork during DNA …
[HTML][HTML] Epigenetics in the hematologic malignancies
CY Fong, J Morison, MA Dawson - Haematologica, 2014 - ncbi.nlm.nih.gov
… In eukaryotes, the catalytic activity of a family of enzymes known as DNA methyltransferases
(DNMTs) results in the addition of a methyl group to the five-carbon position of cytosine …
(DNMTs) results in the addition of a methyl group to the five-carbon position of cytosine …
DNA methylation changes in hematologic malignancies: biologic and clinical implications.
… Finally, reactivation of tumor-suppressor gene expression through pharmacologic inhibition
of DNA methyltransferase and resultant DNA demethylation appears to be a promising new …
of DNA methyltransferase and resultant DNA demethylation appears to be a promising new …
Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies
A Zhao, H Zhou, J Yang, M Li, T Niu - Signal Transduction and Targeted …, 2023 - nature.com
… of DNA methylation and histone methylation, and acetylation in hematologic malignancies.
… and long noncoding RNAs on hematologic malignancies. Furthermore, the implication of …
… and long noncoding RNAs on hematologic malignancies. Furthermore, the implication of …
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