… Defining the role of each particular heme iron acquisition system in virulence is ongoing for
many pathogens, but has been complicated by the presence of redundant systems in some …

… For the sake of simplicity in this review, heme will refer to ferrous and ferric iron forms of
protoheme IX. Heme is then … Isd-mediated heme acquisition is vital to the virulence of S. aureus. …

… heme, salmochelin and aerobactin systems in the virulence of APEC E058 and UPEC U17
were assessed. Results indicated that the contribution of these three distinct iron acquisition …

… Iron acquisition is critical for virulence of the human pathogenic … iron and abundant in
iron-starved cells, suggesting a role in … in the acquisition of iron from heme and the virulence of C. …

… virulence, in C. neoformans. Overall, this study extends our understanding of iron acquisition
… neoformans, reveals an additional complexity to the connection between iron and virulence …

… transport-associated proteins (ChtA, ChtB, and ChtC), but further efforts are required to
elucidate the means by which these systems cooperatively promote heme-iron acquisition in this …

… on heme iron as sole iron source, whereas the parental and complemented strains can.
The lack of CodY-mediated transcription weakens virulence by controlling iron acquisition and …

… , heme-hemopexin, and heme-albumin (140). Another mechanism for iron acquisition by …
hemolysins, which release iron complexed to intracellular heme and hemoglobin. Synthesis …

… This result, along with the discoveries of a role for Fre2 in iron acquisition from heme and a
contribution of Fre4 to production of the virulence factor melanin, served to focus our attention …

… major sources of iron include heme and heme proteins, the iron-storage protein ferritin, and
… other virulence factors occurs. The type of iron acquisition system and its role in virulence …