Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level

CJ Chen, HI Yang, JUN Su, CL Jen, SL You, SN Lu… - Jama, 2006 - jamanetwork.com
… gradient of hepatocellular carcinoma risk by (1) serum HBV DNA levels at … serum ALT level,
and presence of liver cirrhosis at study entry; and (2) persistent elevation of serum HBV DNA

Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA

YJ Zhang, HC Wu, J Shen, H Ahsan, WY Tsai… - Clinical Cancer …, 2007 - AACR
… in serum DNA for early detection of HCC. Experimental Design: Aberrant promoter
hypermethylation was investigated in DNA isolated from the serum of … was found in serum DNA 1 …

Total serum DNA and DNA integrity: diagnostic value in patients with hepatitis B virus-related hepatocellular carcinoma

H Chen, L Sun, H Zheng, Q Zhang… - Pathology-Journal of the …, 2012 - journals.lww.com
serum cell-free DNA (cfDNA) and DNA integrity index for detection of hepatitis B virus (HBV)-related
hepatocellular carcinoma … of beta-actin genomic DNA fragments using two sets of …

Changes in serum levels of HBV DNA and alanine aminotransferase determine risk for hepatocellular carcinoma

CF Chen, WC Lee, HI Yang, HC Chang, CL Jen… - Gastroenterology, 2011 - Elsevier
… change in serum levels of HBV DNA over time is a strong risk predictor of hepatocellular
carcinoma, … Spontaneous decrease of HBV DNA levels to <10 4 copies/mL is associated with a …

Detection of mitochondrial DNA alterations in the serum of hepatocellular carcinoma patients

O Okochi, K Hibi, T Uemura, S Inoue, S Takeda… - Clinical cancer …, 2002 - AACR
serum because mtDNA has a higher copy number than nuclear DNA. Thus, we examined
genetic alterations in the D-loop region of mtDNA in hepatocellular carcinoma (HCC) patients. …

Quantitative analysis of circulating methylated DNA as a biomarker for hepatocellular carcinoma

KCA Chan, PBS Lai, TSK Mok, HLY Chan… - Clinical …, 2008 - academic.oup.com
… We used 5 μL of DNA not treated with enzyme or 7.15 μL of an enzyme-digested serum
DNA mixture (equivalent to 5 μL of undigested serum DNA) as the template for each reaction. …

Using circulating tumor DNA as a novel biomarker to screen and diagnose hepatocellular carcinoma: A systematic review and meta‐analysis

Z Zhang, P Chen, H Xie, P Cao - Cancer medicine, 2020 - Wiley Online Library
… diagnostic accuracy of circulating tumor DNA (ctDNA) in hepatocellular carcinoma (HCC). …
Circulating tumor DNA displays a promising diagnostic potential in HCC. However, it is not …

Circulating tumor DNA and hepatocellular carcinoma

JD Yang, MC Liu, JB Kisiel - Seminars in liver disease, 2019 - thieme-connect.com
… biomarkers in hepatocellular carcinoma (HCC). Circulating cell free deoxyribonucleic acid
(cfDNA) is a fragmented DNA subtype, found in the blood circulation. Circulating tumor DNA (…

[HTML][HTML] Circulating DNA level is negatively associated with the long-term survival of hepatocellular carcinoma patients

N Ren, QH Ye, LX Qin, BH Zhang, YK Liu… - World journal of …, 2006 - ncbi.nlm.nih.gov
… Furthermore, while serum DNA is significantly associated … DNA is predictive of recurrence,
indicating that serum DNA … that plasma DNA better reflects the in vivo levels of circulating DNA[…

Quantitation of plasma circulating DNA using quantitative PCR for the detection of hepatocellular carcinoma

Z Huang, D Hua, Y Hu, Z Cheng, X Zhou, Q Xie… - Pathology & Oncology …, 2012 - Springer
… The potential diagnostic, prognostic, and monitoring significance of plasma/serum DNA
has been clearly demonstrated in breast cancer [5, 6], colorectal cancer [3], lung cancer [7–9], …