Regulation of gene expression by HIF‐1
GL Semenza, LA Shimoda… - Signalling Pathways in …, 2006 - Wiley Online Library
… First, HIF-1 is … HIF-1a deficiency manifest developmental defects that involve all three
components of the circulatory system. Second, HIF-1 mediates changes in gene expression that …
components of the circulatory system. Second, HIF-1 mediates changes in gene expression that …
HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery
GL Semenza - Current pharmaceutical design, 2009 - ingentaconnect.com
… -Lindau (VHL) protein to HIF-1α that has been hydroxylated at … and changes in gene
expression through HIF-1 activation. … Analysis of hypoxia-inducible factor 1α expression and its …
expression through HIF-1 activation. … Analysis of hypoxia-inducible factor 1α expression and its …
Regulation of gene expression by oxygen: NF-κB and HIF-1, two extremes
… the activation of specific transcription factors and expression of appropriate target genes.
The aim of this review is to describe how hypoxia-inducible factor-1 (HIF-1) and nuclear factor-…
The aim of this review is to describe how hypoxia-inducible factor-1 (HIF-1) and nuclear factor-…
O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1
GL Semenza - Journal of Applied Physiology, 2004 - journals.physiology.org
… gene expression that are mediated by the transcriptional activator hypoxia-inducible factor
(HIF… at the locus encoding the O 2 -regulated HIF-1α or HIF-2α subunit has revealed that these …
(HIF… at the locus encoding the O 2 -regulated HIF-1α or HIF-2α subunit has revealed that these …
Hypoxia-inducible factor 1 alpha (HIF-1α) gene expression in human ovarian carcinoma
K Nakayama, A Kanzaki, K Hata, H Katabuchi… - Cancer letters, 2002 - Elsevier
… Hypoxia-inducible factor 1α (HIF-1α) that regulates genes … examine the expression of HIF-1α
and VEGF gene expressions and … analyzed HIF-1α and VEGF gene expression levels using …
and VEGF gene expressions and … analyzed HIF-1α and VEGF gene expression levels using …
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
CJ Hu, LY Wang, LA Chodosh, B Keith… - Molecular and cellular …, 2003 - Taylor & Francis
… HIF-1α and HIF-2α target genes, we demonstrate that HIF-2α does regulate a variety of broadly
expressed hypoxia-inducible genes, … gene expression, we show for the first time that HIF-…
expressed hypoxia-inducible genes, … gene expression, we show for the first time that HIF-…
Hypoxia-inducible factor (HIF1α) gene expression in human shock states
J Textoris, N Beaufils, G Quintana, A Ben Lassoued… - Critical Care, 2012 - Springer
… show the increased expression of HIF1α, a transcription factor that controls genes implied in
… Within the limitations of the study, HIF1α expression was not correlated with the outcome of …
… Within the limitations of the study, HIF1α expression was not correlated with the outcome of …
Loss of PTEN facilitates HIF-1-mediated gene expression
W Zundel, C Schindler, D Haas-Kogan… - Genes & …, 2000 - genesdev.cshlp.org
… Akt-induced HIF-1α stabilization and transactivation is not a result of direct phosphorylation
of HIF-1α, we used HIF-1α as a substrate in in vitro kinase assays (Fig. 5C). HIF-1α was a …
of HIF-1α, we used HIF-1α as a substrate in in vitro kinase assays (Fig. 5C). HIF-1α was a …
Up‐regulation of gene expression by hypoxia is mediated predominantly by hypoxia‐inducible factor 1 (HIF‐1)
AE Greijer, P Van Der Groep… - The Journal of …, 2005 - Wiley Online Library
… Furthermore, seven cDNAs from genes with unknown function or expressed sequence …
gene expression and HIF-1 seems to play a major role in the regulation of hypoxia-induced genes…
gene expression and HIF-1 seems to play a major role in the regulation of hypoxia-induced genes…
[HTML][HTML] Inhibition of PPARγ2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia
Z Yun, HL Maecker, RS Johnson, AJ Giaccia - Developmental cell, 2002 - cell.com
… HIF-1α or HIF-1β is embryonically lethal. The HIF-1α −/− embryos succumb, between 9 and
10 days postcoitum (dpc), to loss of mesenchymal cells and impaired vascular development ( …
10 days postcoitum (dpc), to loss of mesenchymal cells and impaired vascular development ( …
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