… have found that HIF-1α activity increases in HCT116 colorectal tumor cells following exposure
to intermittent hypoxia mimicking OSA. This increases the expression of HIF-target gene …

… protein levels obviously increased at 4 h under hypoxia or mimic hypoxia in HCT116 (…
HIF-1α protein expression in HCT116 cells. The results showed that BRU down-regulated HIF-1α …

… In order to further demonstrate the relationship between PI3K/Akt and HIF-1α in hypoxia, we
stimulated HCT116 cells with 10 ng/mL IGF-I for 2 h. As shown in Figure 7, the expression of …

… could inhibit hypoxia-inducible factor 1α (HIF-1α) expression and also impair its function (25).
HIF-1α is a central regulator of hypoxic response in many cell types, including cancer cells (…

… To determine the effects of specifically inhibiting HIF-1 on … cell lines that do not express
HIF-1α: HCT116 HIF-1α-/- , HCT15 … HIF-αs genes in HCT116 cells to generate the HCT116 HIF-…

… , HIF-1α protein levels increase as compared to normoxic HCT116 cells, where HIF-1α protein
is barely detectable; HIF-… of hypoxic HCT116 cells to 5FU, we engineered two different cell …

… HIF-1α, c-Myc and p21 in cells grown in normoxia or hypoxia for 24 h and cell-cycle analyses
for HCT116 and SW480 cells … HIF-1α was induced in normoxic HCT116 and SW480 cells …

… HIF-1α by targeted homologous recombination in HCT116 … Both HCT116 HIF-1α−/− and
RKO HIF-1α−/− cells underwent … with their parental cells (Fig. 2B). These data reaffirm that …

… In this study, we showed that sulforaphane inhibited HIF-1α protein expression in HCT116
and AGS cells under hypoxic conditions. In addition, sulforaphane treatment inhibited hypoxia-…

… BCL-9 expression levels was determined in HCT116 cells with knock-down of endogenous
HIF-1α or HIF-2α by siRNA. As shown in Figure ​5A and ​5B, knock-down of endogenous …