The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape
DN Weinberg, S Papillon-Cavanagh, H Chen, Y Yue… - Nature, 2019 - nature.com
… H3K36me2 is required for the recruitment of DNMT3A and maintenance of DNA methylation
… that the binding and activity of DNMT3A colocalize with H3K36me2 at non-coding regions of …
… that the binding and activity of DNMT3A colocalize with H3K36me2 at non-coding regions of …
DNMT3A reads and connects histone H3K36me2 to DNA methylation
… In order to understand the biological impact of the axis of histone H3K36me2 and DNA
5mC, we turned to a well-characterized multiple myeloma model, KMS11 and KMS11 TKO . …
5mC, we turned to a well-characterized multiple myeloma model, KMS11 and KMS11 TKO . …
[HTML][HTML] Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes
S Yano, T Ishiuchi, S Abe, SH Namekawa… - Nature …, 2022 - nature.com
… possible involvement of this histone mark in de novo DNA methylation in oocytes and find
that H3K36me2 is selectively required for DNA methylation in moderately methylated regions. …
that H3K36me2 is selectively required for DNA methylation in moderately methylated regions. …
Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3
K Finogenova, J Bonnet, S Poepsel, IB Schäfer, K Finkl… - elife, 2020 - elifesciences.org
… DNA and the H3 N-terminus that enable the histone methylation marks H3K36me2 and …
from depositing the repressive histone methylation mark H3K27me3 at transcribed genes. …
from depositing the repressive histone methylation mark H3K27me3 at transcribed genes. …
Understanding histone H3 lysine 36 methylation and its deregulation in disease
… H3K36me2 and DNA methylation is from an observation that CpG islands (CGIs) are normally
refractory to DNA methylation and also are uniquely devoid of H3K36me2 [77]. Here, un-…
refractory to DNA methylation and also are uniquely devoid of H3K36me2 [77]. Here, un-…
[HTML][HTML] Structural and functional specificity of H3K36 methylation
… linker DNA and a hydrophobic patch constituted by histone … to the regulation of H3K36me2
to H3K36me3 conversion. We … global DNA methylation profiles in these patients [108, 110]. …
to H3K36me3 conversion. We … global DNA methylation profiles in these patients [108, 110]. …
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
… The mechanism by which loss of intergenic H3K36me2 and DNA methylation affects gene …
the dosage of NSD2 and H3K36me2 is linked to the binding of methylation-sensitive genome …
the dosage of NSD2 and H3K36me2 is linked to the binding of methylation-sensitive genome …
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
… of H3K27me3 and H3K36me2/3 (fig. S11A) (16). We observed a genome-wide loss of
H3K36me2/3 and a concomitant increase in H3K27me3 in H3.3K36M cells (Fig. 3, A and B). …
H3K36me2/3 and a concomitant increase in H3K27me3 in H3.3K36M cells (Fig. 3, A and B). …
[PDF][PDF] NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons
N Hamagami, DY Wu, AW Clemens, SA Nettles, A Li… - Molecular cell, 2023 - cell.com
… -scale H3K36me2 and nonCG methylation in neurons. We find that brain-specific deletion
of NSD1 causes altered DNA methylation … of H3K36me2, DNMT3A, and DNA methylation at …
of NSD1 causes altered DNA methylation … of H3K36me2, DNMT3A, and DNA methylation at …
[HTML][HTML] The interplay between H3K36 methylation and DNA methylation in cancer
J Dan, Z Du, J Zhang, T Chen - Cancer Biology & Medicine, 2023 - ncbi.nlm.nih.gov
… role of H3K36 methylation marks in guiding DNA methylation patterns. The major histone
PTMs (… Thus, H3K36me2/me3-dependent de novo methylation functions in promoting normal …
PTMs (… Thus, H3K36me2/me3-dependent de novo methylation functions in promoting normal …
相关搜索
- dna methylation patterns
- intragenic dna methylation
- dna methylation landscape
- histone h3k36me2 dnmt3a dependent dna methylation
- histone 3 lysine dna methylation
- histone modifications dna methylation
- dnmt3b mediated dna methylation
- regional dna methylation
- dna methylation fidelity
- mechanisms of dna methylation and demethylation
- dna methylation and chromatin
- dna methylation in development
- independent of dna methylation
- cancer dna methylation
- maintenance dna methylation
- histone h3k36me2 chromatin platform