The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

DN Weinberg, S Papillon-Cavanagh, H Chen, Y Yue… - Nature, 2019 - nature.com
H3K36me2 is required for the recruitment of DNMT3A and maintenance of DNA methylation
… that the binding and activity of DNMT3A colocalize with H3K36me2 at non-coding regions of …

DNMT3A reads and connects histone H3K36me2 to DNA methylation

W Xu, J Li, B Rong, B Zhao, M Wang, R Dai… - Protein & …, 2020 - academic.oup.com
… In order to understand the biological impact of the axis of histone H3K36me2 and DNA
5mC, we turned to a well-characterized multiple myeloma model, KMS11 and KMS11 TKO . …

[HTML][HTML] Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes

S Yano, T Ishiuchi, S Abe, SH Namekawa… - Nature …, 2022 - nature.com
… possible involvement of this histone mark in de novo DNA methylation in oocytes and find
that H3K36me2 is selectively required for DNA methylation in moderately methylated regions. …

Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3

K Finogenova, J Bonnet, S Poepsel, IB Schäfer, K Finkl… - elife, 2020 - elifesciences.org
DNA and the H3 N-terminus that enable the histone methylation marks H3K36me2 and …
from depositing the repressive histone methylation mark H3K27me3 at transcribed genes. …

Understanding histone H3 lysine 36 methylation and its deregulation in disease

J Li, JH Ahn, GG Wang - Cellular and Molecular Life Sciences, 2019 - Springer
H3K36me2 and DNA methylation is from an observation that CpG islands (CGIs) are normally
refractory to DNA methylation and also are uniquely devoid of H3K36me2 [77]. Here, un-…

[HTML][HTML] Structural and functional specificity of H3K36 methylation

UTF Lam, BKY Tan, JJX Poh, ES Chen - Epigenetics & Chromatin, 2022 - Springer
… linker DNA and a hydrophobic patch constituted by histone … to the regulation of H3K36me2
to H3K36me3 conversion. We … global DNA methylation profiles in these patients [108, 110]. …

The interplay between DNA and histone methylation: molecular mechanisms and disease implications

Y Li, X Chen, C Lu - EMBO reports, 2021 - embopress.org
… The mechanism by which loss of intergenic H3K36me2 and DNA methylation affects gene …
the dosage of NSD2 and H3K36me2 is linked to the binding of methylation-sensitive genome …

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

C Lu, SU Jain, D Hoelper, D Bechet, RC Molden, L Ran… - Science, 2016 - science.org
… of H3K27me3 and H3K36me2/3 (fig. S11A) (16). We observed a genome-wide loss of
H3K36me2/3 and a concomitant increase in H3K27me3 in H3.3K36M cells (Fig. 3, A and B). …

[PDF][PDF] NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons

N Hamagami, DY Wu, AW Clemens, SA Nettles, A Li… - Molecular cell, 2023 - cell.com
… -scale H3K36me2 and nonCG methylation in neurons. We find that brain-specific deletion
of NSD1 causes altered DNA methylation … of H3K36me2, DNMT3A, and DNA methylation at …

[HTML][HTML] The interplay between H3K36 methylation and DNA methylation in cancer

J Dan, Z Du, J Zhang, T Chen - Cancer Biology & Medicine, 2023 - ncbi.nlm.nih.gov
… role of H3K36 methylation marks in guiding DNA methylation patterns. The major histone
PTMs (… Thus, H3K36me2/me3-dependent de novo methylation functions in promoting normal …