… In each case, low levels of histone H3K36me2 was found in the highly expressed genes,
whereas high levels of H3K36me2 was detected in all three weakly expressed genes (Figure …

… histone H3 at lysine 36 (H3K36me2) is the principal chromatin-regulatory activity of NSD2.
Catalysis of H3K36me2 … and gene-specific distribution of H3K36me2 is obliterated, creating a …

… , H3K36me2 or both marks, we modulated cognate histone … We hypothesized that
differential DNA methylation patterns … preferences because DNA methylation typically restrains …

… NSD1 on DNA methylation, H3K27me3, histone acetylation … H3K36me2 domains and less
free DNMT3A would be available for genome methylation leading to reduced DNA methylation…

… Furthermore, our data suggest that both methylation of H3K36me2 and demethylation of
H3K27me3 are required for MMSET to fully alter gene expression observed in myeloma. …

… While the NSD1-3 enzymes mediate the bulk of H3K36me1 and H3K36me2 throughout the
… transcription elongation, histone deacetylation, and/or DNA methylation. Additionally, the …

… H3K36me3 and lowers the amount of H3K36me2 more than two‐fold. However, Rpd3S
retains its normal function, as we did not observe any histone acetylation defects or a cryptic …

… Di- and tri-methylation of lysine 36 on histone H3 (H3K36me2/3) is catalysed by histone
methyltransferase Set2, which plays an essential role in transcriptional regulation. Although …

… typical histone lysine methyltransferase, which mainly catalyses the formation of H3K36me2
and … In this study, we found that histone methylation was involved in pathological process of …

… the link between histone H3 methylation and MSL complex … of histone H3 at lysine 36 (H3K36me3)
relies on the histone … and a coinciding increase of H3K36me2. H2A serves as a …