… sites of histone posttranslational modifications such as methylation of H3K27 and H3K36. …
encoding human histone H3 being mutated in tumors imply that the mutations are dominant or …

… tails containing H3G34 mutations 10,11,12 , making it ideal to further study the molecular …
of oncogenic histone mutations in regulating H3K36 methylation. Mutations of other methylated …

… To investigate whether H3G34 mutations affect H3K36 methylation, we performed an in
vitro histone lysine methyltransferase (HKMT) assay using the purified human SETD2 catalytic …

… Deregulation of H3K36 methylation and related regulatory … , recurrent mutations of H3K36
and surrounding histone … current advances in understanding H3K36 methylation and related …

… by histone H2A and H3 are likely determinants of H3K36 … cells, mutations in Set2 or H3K36
lead to a decreased lifespan, presumably by reasons of a global loss of histone methylation […

… Here we report that unlike the K27M or K36M that affect global histone methylation, … mutations
(G34L/W) only affect histone H3K36 and H3K27 methylation on the same mutated histone …

… We summarize the biological significance of H3K36 methylation for normal cell
processes and discuss recently proposed oncohistone-driven tumorigenic mechanisms. …

… IDH mutations. Taken together, our results suggest that mutations disrupting the histone code
at H3K36… G34R/V, IDH1 and/or SETD2 mutations, are central to the genesis of hemispheric …

… , this newfound role for recruitment of histone deacetylase is particularly exciting. One can
envision a role for histone H3K36 methylation and Rpd3S histone deacetylase recruitment …

… histone modification, H3K27 trimethylation (H3K27me3) (10, 11, 13). H3K36 methylation is
… In H3K36M-mutant cells, the reduction in H3K36 methylation causes a widespread increase …