Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
… sites of histone posttranslational modifications such as methylation of H3K27 and H3K36. …
encoding human histone H3 being mutated in tumors imply that the mutations are dominant or …
encoding human histone H3 being mutated in tumors imply that the mutations are dominant or …
Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation
… tails containing H3G34 mutations 10,11,12 , making it ideal to further study the molecular …
of oncogenic histone mutations in regulating H3K36 methylation. Mutations of other methylated …
of oncogenic histone mutations in regulating H3K36 methylation. Mutations of other methylated …
Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction
… To investigate whether H3G34 mutations affect H3K36 methylation, we performed an in
vitro histone lysine methyltransferase (HKMT) assay using the purified human SETD2 catalytic …
vitro histone lysine methyltransferase (HKMT) assay using the purified human SETD2 catalytic …
Understanding histone H3 lysine 36 methylation and its deregulation in disease
… Deregulation of H3K36 methylation and related regulatory … , recurrent mutations of H3K36
and surrounding histone … current advances in understanding H3K36 methylation and related …
and surrounding histone … current advances in understanding H3K36 methylation and related …
Structural and functional specificity of H3K36 methylation
… by histone H2A and H3 are likely determinants of H3K36 … cells, mutations in Set2 or H3K36
lead to a decreased lifespan, presumably by reasons of a global loss of histone methylation […
lead to a decreased lifespan, presumably by reasons of a global loss of histone methylation […
Histone H3. 3 G34 mutations alter histone H3K36 and H3K27 methylation in cis
… Here we report that unlike the K27M or K36M that affect global histone methylation, … mutations
(G34L/W) only affect histone H3K36 and H3K27 methylation on the same mutated histone …
(G34L/W) only affect histone H3K36 and H3K27 methylation on the same mutated histone …
Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers
BJ Klein, K Krajewski, S Restrepo, PW Lewis… - Epigenetics, 2018 - Taylor & Francis
… We summarize the biological significance of H3K36 methylation for normal cell
processes and discuss recently proposed oncohistone-driven tumorigenic mechanisms. …
processes and discuss recently proposed oncohistone-driven tumorigenic mechanisms. …
Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
AM Fontebasso, J Schwartzentruber… - Acta …, 2013 - Springer
… IDH mutations. Taken together, our results suggest that mutations disrupting the histone code
at H3K36… G34R/V, IDH1 and/or SETD2 mutations, are central to the genesis of hemispheric …
at H3K36… G34R/V, IDH1 and/or SETD2 mutations, are central to the genesis of hemispheric …
A site to remember: H3K36 methylation a mark for histone deacetylation
JS Lee, A Shilatifard - Mutation Research/Fundamental and Molecular …, 2007 - Elsevier
… , this newfound role for recruitment of histone deacetylase is particularly exciting. One can
envision a role for histone H3K36 methylation and Rpd3S histone deacetylase recruitment …
envision a role for histone H3K36 methylation and Rpd3S histone deacetylase recruitment …
Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3. 3K36M oncohistone mutation
KN Rajagopalan, X Chen… - Proceedings of the …, 2021 - National Acad Sciences
… histone modification, H3K27 trimethylation (H3K27me3) (10, 11, 13). H3K36 methylation is
… In H3K36M-mutant cells, the reduction in H3K36 methylation causes a widespread increase …
… In H3K36M-mutant cells, the reduction in H3K36 methylation causes a widespread increase …
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