… cellular physiology. In this review, we will discuss the molecular details of the involvement of
DNA methylation … by DNA methylation, in specific human genetic syndromes and in cancer. …

… DNA methylation, we used datasets from the Roadmap Epigenomics Project of 35 human
cells … This enabled us to perform an extensive analysis in a wide variety of human cells. We …

… induced pluripotent stem cells (iPSCs). Here, we determined the DNA methylation profiles
of 22 human iPSC lines derived from five different cell types (human endometrium, placental …

… At least four types of viruses involved in human lung cancerogenesis can be inactivated in …
of cytosine methylation has not been found in human tumours for many years. In human cells, …

… expression in iPS cells We next analysed available data on genome-wide DNA methylation
in ES cells and fibroblasts 21 . The top incompletely silenced genes in iPS cells, such as …

… DNA methylation model that explains all findings and provides a unified description of both
the de novo and the maintenance methylation … , non-CpG methylation in human cells and in …

… DNA methylation between lymphoid and myeloid cells and identified many CpG sites that
were differentially methylated … Interestingly, B cells showed the most unique profile, suggesting …

… cellular differentiation and homeostasis. During development, different cell types acquire
distinct DNA methylation … For most genes, the pattern of DNA methylation is identical on both …

… Preclinical studies on decitabine have shown that it reverses methylation in a number of
cell lines and in cells from human leukemia patients. Clinical trials in solid tumors showed …

… the significance of these patterns for normal cellular development, we are just beginning
to … of DNA methylation patterns for human diseases. In mammals, cytosine methylation is …