… and neurological disorders. Studies in recent years have … and DNA methylation with cancer
and other diseases has been … in components of the DNA methylation machinery. While the …

… machinery that regulates DNA methylation patterns and chromatin structure also contribute to
human disease. … only on those diseases for which defective DNA methylation patterns have …

… the recent studies in DNA methylation primarily focusing on the … gene silencing in development
and disease. Although the molecular … The DNA methylation machinery. The mammalian …

… and re-establishment of DNA methylation in embryonic, germline … into DNA methylation
gained from studying genetic diseases. … of recruiting the DNA methylation machinery to ensure …

… tuned machinery leading to gene regulation. Here, we review the impact of the studies on
DNA methylation, … The effect of deregulation of DNA methylation on human health, will be also …

… hypermethylation. Here we review recent findings on altered DNA methylation in human
disease, … DNA methylation machinery and the Polycomb-Trithorax (Pcg-TrxG) family of proteins. …

… In summary, the disruption of the epigenetic machinery and their patterns are a major hallmark
of human cancer, at the same level as the genetic and environmental settings. Research …

… human diseases, including cancer. Thus, understanding functional genetic mutations and
aberrant expression of these DNA methylation … significance of DNA methylation machinery and …

… DNA methylation could provide a valuable tool for monitoring tissue dynamics and diagnosing
multiple diseases. … them and then recruited the methylation machinery. This secondary …

… Changes in human DNA methylation patterns are … diseases (eg, multiple sclerosis and
lupus) is being recognised. The cancer genome is frequently characterised by hypermethylation …