Hippocampus and its involvement in Alzheimer's disease: a review

YL Rao, B Ganaraja, BV Murlimanju, T Joy… - 3 Biotech, 2022 - Springer
hippocampus is one of the brain areas affected by Alzheimer’s (AD). In the early stages of
AD, the hippocampus … In the progression of AD, atrophy of medial temporal and hippocampal

Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease

G Šimić, I Kostović, B Winblad… - Journal of Comparative …, 1997 - Wiley Online Library
… changes owing to aging and Alzheimer’s disease (AD) in the volumes of subdivisions of
the hippocampus and the number of neurons of the hippocampal formation, 18 normal brains …

The CA1 region of the human hippocampus is a hot spot in Alzheimer's disease

MJ West, CH Kawas, LJ Martin… - Annals of the New York …, 2000 - Wiley Online Library
… total number of neurons in the five major subdivisions of the hippocampal regions of the
brains of patients with Alzheimer's disease (AD) and normal age-matched controls confirm an …

[PDF][PDF] Human hippocampal neurogenesis persists in aged adults and Alzheimer's disease patients

MK Tobin, K Musaraca, A Disouky, A Shetti, A Bheri… - Cell stem cell, 2019 - cell.com
… in the human brain is not fully resolved. Here, we demonstrate that hippocampal neurogene…
in patients with mild cognitive impairments and Alzheimer’s disease. In a cohort of 18 par…

Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease

JW Geddes, H Chang-Chui, SM Cooper, IT Lott… - Brain research, 1986 - Elsevier
… sites in human hippocampal samples obtained postmortem from Alzheimer's disease (AD) …
NMDA receptors were concentrated in the terminal fields of major hippocampal pathways …

Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology

DH Adler, LEM Wisse, R Ittyerah… - Proceedings of the …, 2018 - National Acad Sciences
… of hippocampal subfields. Serial histological imaging in 9 of the 31 specimens was used to
label hippocampal … in patients with a clinical diagnosis of Alzheimer's disease (AD; 9 subjects, …

Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease

DC Hondius, P van Nierop, KW Li… - Alzheimer's & …, 2016 - Elsevier
… quantitative proteomics study on human hippocampus tissue involving all Braak stages
to assess changes in protein abundance over the various stages of Alzheimer's disease (AD). …

Functional segmentation of the hippocampus in the healthy human brain and in Alzheimer's disease

M Zarei, CF Beckmann, MAA Binnewijzend… - Neuroimage, 2013 - Elsevier
… We conclude that the human hippocampus consists of three functionally distinct regions
in which resting state activity is correlated with activities in the thalamus, the prefrontal cortex …

… and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer's disease

C Venkateshappa, G Harish, A Mahadevan… - Neurochemical …, 2012 - Springer
… ’s disease. To understand whether aging contributes to the vulnerability of brain regions in
Alzheimer’s disease, we … complex I (CI) activity in hippocampus (HC) and frontal cortex (FC) …

Reduced neurogenesis in human hippocampus with Alzheimer's disease

Y Cao, P Liu, H Bian, S Jin, J Liu, N Yu, H Cui… - Brain …, 2024 - Wiley Online Library
… AHN and neurodegenerative diseases, particularly AD, has not yet been confirmed in humans.
In this research, we obtained high-quality human hippocampal tissue samples evaluated …