[HTML][HTML] Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways
L Dearden, S Buller, IC Furigo… - Molecular …, 2020 - Elsevier
… Hypothalamic fetal gene expression and neurosphere growth correlated with maternal body
weight … alterations in offspring hypothalamic anatomy or gene expression in adulthood after …
weight … alterations in offspring hypothalamic anatomy or gene expression in adulthood after …
Developmental programming of hypothalamic feeding circuits
SG Bouret, RB Simerly - Clinical genetics, 2006 - Wiley Online Library
… important consequences for normal body weight regulation and glucose homeostasis later
… may have long-term consequences on body weight regulation and adiposity in the offspring. …
… may have long-term consequences on body weight regulation and adiposity in the offspring. …
[HTML][HTML] Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning
G Begum, A Stevens, EB Smith, K Connor… - The FASEB …, 2012 - ncbi.nlm.nih.gov
… a 10–15% reduction in body weight. Fetal ventral hypothalami … We analyzed mRNA expression
of the POMC gene in the … offspring that are overweight compared with control offspring at …
of the POMC gene in the … offspring that are overweight compared with control offspring at …
Sex-specific epigenetic alterations of the hypothalamic Agrp-Pomc system do not explain 'diabesity'in the offspring of high-fat diet (HFD) overfed maternal rats
K Schellong, K Melchior, T Ziska, W Henrich… - The Journal of …, 2020 - Elsevier
… body weights of adult offspring at day … hypothalamic gene expression of offspring Against
the background of this ‘diabesogenic’ phenotype, we evaluated hypothalamic gene expression …
the background of this ‘diabesogenic’ phenotype, we evaluated hypothalamic gene expression …
Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health
… many insults that affect offspring biology do not alter gross birth weight. Two mechanistic …
weight. Glucocorticoid administration reduces foetal growth and stably alters gene expression …
weight. Glucocorticoid administration reduces foetal growth and stably alters gene expression …
Exposure to chlorpyrifos at different ages triggers APOE genotype-specific responses in social behavior, body weight and hypothalamic gene expression
P Basaure, L Guardia-Escote, J Biosca-Brull… - Environmental …, 2019 - Elsevier
… social behavior and hypothalamic gene expression in apoE-… During adult exposure to CPF,
body weight gain and food … test, as well as mRNA levels of hypothalamic neuropeptides and …
body weight gain and food … test, as well as mRNA levels of hypothalamic neuropeptides and …
Maternal and post-weaning high-fat, high-sucrose diet modulates glucose homeostasis and hypothalamic POMC promoter methylation in mouse offspring
J Zheng, X Xiao, Q Zhang, M Yu, J Xu, Z Wang… - Metabolic brain …, 2015 - Springer
… in the neuroendocrine control of body weight and energy … gene expressions of hypothalamus
in the offspring. As expected, the expression of POMC and MC4R in the hypothalamus both …
in the offspring. As expected, the expression of POMC and MC4R in the hypothalamus both …
[HTML][HTML] Stage-specific inhibition of TrkB activity leads to long-lasting and sexually dimorphic effects on body weight and hypothalamic gene expression
MS Byerly, RD Swanson, GW Wong, S Blackshaw - PLoS One, 2013 - journals.plos.org
… It remains to be determined whether TrkB inhibition alters maternal feeding behavior to
induce sex-specific changes in hypothalamic neural circuitry of offspring. However, the E14–E18 …
induce sex-specific changes in hypothalamic neural circuitry of offspring. However, the E14–E18 …
[HTML][HTML] Early hypothalamic FTO overexpression in response to maternal obesity–potential contribution to postweaning hyperphagia
… body weight was significantly correlated with hypothalamic … the association between
hypothalamic FTO mRNA expression at … in FTO expression may be present earlier in life in …
hypothalamic FTO mRNA expression at … in FTO expression may be present earlier in life in …
Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring
… acting on the hypothalamus, as well as hypothalamic gene expression, in adult offspring.
The … Body weight and food intake of the offspring were measured weekly until adulthood. All …
The … Body weight and food intake of the offspring were measured weekly until adulthood. All …