[HTML][HTML] Underestimated aspects in male infertility: epigenetics is a new approach in men with obesity or diabetes: a review

M Jazayeri, A Alizadeh, MAS Gilani… - … Journal of Fertility & …, 2022 - ncbi.nlm.nih.gov
… have mostly concentrated on imprinted genes like H19, IGF2, MEST, PEG3, LIT1, SNRPN
and KCNQ1 in addition to some non-imprinted genes, like MTHFR and DAZL. These studies …

H19 DMR methylation correlates to the progression of esophageal squamous cell carcinoma through IGF2 imprinting pathway

T Gao, B He, Y Pan, L Gu, L Chen, Z Nie, Y Xu… - Clinical and …, 2014 - Springer
… that H19 CBS6 hypermethylation is related to the LOI of IGF2 which usually leads to an
overexpression of IGF2… Therefore, H19 CBS6 methylation potentially represents a novel clinically …

Aberrant epigenetic modifications in male infertility

S Rajender, A Agarwal - The Open Reproductive Science …, 2011 - benthamopen.com
… Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men. Eur J …
male infertility is strongly associated with aberrant methylation of MEST and IGF2/H19 ICR1. …

Lability of imprinting in extraembryonic tissue

QV Neri, T Takeuchi, Z Rosenwaks, GD Palermo - Fertility and Sterility, 2008 - fertstert.org
… for the target sequence of Igf2, H19, and Igf2r genes. … specimen, the analysis of placental
tissue evidenced a down regulation of H19 (P<0.001) and concurrent under expression of Igf2 (…

GENETICS: I-50: EMBRYO LOSS DUE TO EPIGENETIC ANOMALIES IN THE MALE GERM LINE: ROLE OF ESTROGEN

SHG PATHAK, MN KEDIA, M ANKOLKAR… - 2010 - sid.ir
… and expression of imprinted genes of the Igf2-H19 locus in the spermatozoa and embryos
… at the Igf2-H19 locus during spermatogenesis.Materials and Methods: Adult male rats of …

Does underlying infertility in natural conception modify the epigenetic control of imprinted genes and transposable elements in newborns?

J Barberet, C Binquet, M Guilleman, G Romain… - Reproductive …, 2022 - Elsevier
… The placental DNA methylation levels of H19/IGF2 and KCNQ1OT1 were lower in … for
H19/IGF2 for which the DNA methylation levels were higher in group 2 than in group 1 (H19/IGF2-…

Hepatic IGF2/H19 Epigenetic Alteration Induced Glucose Intolerance in Gestational Diabetes Mellitus Offspring via FoxO1 Mediation

Y Jiang, H Zhu, Z Chen, YC Yu, XH Guo… - Frontiers in …, 2022 - frontiersin.org
… in male offspring, we examined all of the IGF2/H19 DMRs in the liver of GDM-F1 male mice.
… could induce hypermethylation at IGF2-DMR0 and IGF2-DMR1 in GDM-F1 male offspring. …

Poor semen parameters are associated with abnormal methylation of imprinted genes in sperm DNA

B Song, Y Chen, C Wang, G Li, Z Wei, X He… - Reproductive Biology …, 2022 - Springer
… of aberrant H19 methylation in the sperm DNAs of infertile men [16]. … KCNQ1 and IGF-2 have
also been documented to be … In conclusion, our study suggests that in infertile men, the poor …

The effect of laser-assisted hatching on the methylation and expression pattern of imprinted gene IGF2/H19 in mouse blastocysts and offspring

P Huo, K Deng, L Wang, M Li, J Yao, J Le, X Lei… - Journal of Assisted …, 2020 - Springer
… of IGF2/H19 imprinting control region (ICR) and the expression of IGF2 and H19 were …
In a case of male infertility, a baby girl who was born via ICSI had RSS, and it has been …

DNA methylation biomarkers to identify epigenetically abnormal spermatozoa in male partners from couples experiencing recurrent pregnancy loss

K Khambata, S Begum, S Raut, S Mohan, D Irani… - Epigenetics, 2023 - Taylor & Francis
… abnormal spermatozoa, we performed pyrosequencing for IGF2-H19 DMR, IG-DMR, ZAC,
KvDMR, … fertile men who had fathered a child in the past year without any history of infertility or …