… imprinting in spermatozoa from infertile men used for ICSI. … H19 and IGF2 represent the
telomeric domain of the Beckwith… (DMR) in the upstream region of H19 (H19 DMR). The region …

… impaired male fertility with sperm Igf2 … The F1 male offspring were mated with female to
produce F2 progeny. F3 generation was obtained by intercrossing the control and treated male …

… Since the embryos in this study were derived from healthy volunteer couples with proven
fertility among the aforementioned proposition, two possibilities are more likely. Firstly, …

… in infertile men. Gekas et al. performed cytogenetic investigation in 2,196 men undergoing
… Infertile men frequently possess abnormal values in more than one parameter; (3) the …

… Cord blood was collected with a sterile slip-tip 20-ml … were stored separately in sterile
Eppendorf ® tubes containing 1 … were stored separately in sterile Eppendorf tubes containing 1 ml …

… either in the IGF2 DMR2 or in both the IGF2 DMR2 and the sixth CTCF of the H19 DMR was
observed … In idiopathic infertile man, the paternally imprinted IGF2/H19 hypomethylation and …

… H19 DMR is unmethylated in the maternal allele; therefore, H19 expression is allowed, and
admission from the IGF2 … However, methylation of the H19 DMR paternal allele prevents the …

… in understanding molecular mechanism of environmental estrogens impacting male fertility.
… where male specific imprints are acquired. In the present study we have evaluated Igf2/H19 …

… with aberrant methylation status were more likely to have idiopathic infertility (for H19, OR =
7.61, 95% CI = 1.71–33.80; for GNAS, OR = 17.53, 95% CI = 2.29–134.19; for DIRAS3, OR = …

… expression patterns at the Igf2/H19 locus. H19ICR activity is … of the H19ICR in the male germ
line, we characterized novel … America), and dissolved in sterile water. Genomic testis DNA …