… methylation of H19/IGF2 and KCNQ1 genes by two studies. A significantly lower H19
methylation … Cross-sectional studies indicate that male infertility, defined as a history of infertility …

… other factors influencing the expression of H19 and IGF2 in human placental tissue. …
female in the relationship, there is no clear distribution of male and female causes of infertility. …

… Although several specific genetic causes of male infertility have … : H19 is maternally imprinted;
IGF2 is paternally imprinted, meaning that H19 is expressed by the maternal allele, IGF2 …

… It is estimated that about 35% of cases in infertile male are caused by genetic factors (2).
More … of fertile men, H19 leads to IGF2 expression. Repression of H19 transcription increase …

… Furthermore, studies of sperm from infertile men have also … These studies suggest that ART
or infertility may introduce … control region 1 (ICR1) of H19 and IGF2, in the placenta. We also …

… life could alter epigenetic modifications in the male germ-line, increasing the susceptibility …
to induce transgenerational impaired male fertility with sperm Igf2 hypomethylation. However, …

… of infertility in men and women in relation to parameters pertaining to nutrition. The prevalence
of infertility … Yet, methylation pertaining to the H19 DMR allele of paternal sort blocks IGF2 …

… one of the most effective methods for treatment of infertility. Despite high efficiency of these
… male; therefore, female embryos were donated for research. It is important to note that male …

… of H19 and silencing of IGF2 through down-stream enhancer activity. On the paternal allele,
at the IGF2-H19 locus, the ICR and H19 are … of H19 and the expression of IGF2. Consistently, …

… H19 is physically and functionally linked to the IGF2 gene, being … infertile male patients with
a sperm count below 10 × 10 6 /ml display defective methylation of imprinted genes. For H19 …