… affects DNA methylation at IGF2/H19 locus. Nevertheless, genetics … IGF2/H19 locus.
Nevertheless, we have shown that the DNA methylation changes observed at the IGF2/H19 locus …

… Igf2/H19 DMRs were designed and based upon previously published sequences. The
methylation marks of Igf2/H19 … compared the methylation profile of Igf2/H19 DMR3 in each zygote …

… The parent-of-origin-dependent expression of IGF2 and H19 … activation of IGF2 and
biallelic silencing of H19. These … In conclusion, methylation defects at the IGF2-H19 locus can …

… Ohlsson: David Haig once showed me that there is an inverted repeat present in both the
IGF2 and H19 loci, suggesting the formation of a duplex that could antagonize translation. …

… One of the findings in this study is that imprinting at the IGF2-H19 and IGF2R loci is
conserved in a ruminant species, the sheep. In addition, we find aberrant IGF2R methylation in …

… It is clear, therefore, that differential methylation at this locus must be established at a
later point in the developmental program, and the same is true for sites 4 and 6. The …

… of Igf2 and Slc221L. Embryonic stem (ES) cells derived from IVF blastocysts also showed
abnormal Igf2/H19 … ) An enhancer element at the Igf2/H19 locus drives gene expression in both …

… regulation of H19 and IGF2 by … IGF2 imprinting was relaxed in tumours with biallelic H19
hypermethylation, but proliferating epithelial cells from three tumours lacked both H19 and IGF2 …

… The other gene in this locus, H19, is a long non-coding RNA … H19/Igf2 domain have been
previously observed. For example, an analysis of embryonic germ cells showed that H19 is …

… regulatory loci within five DMRs across the IGF2/H19 region … locus specific or extend to
multiple functional loci. We also examined a measure of global methylation to compare the locus-…