Deficiency in hematopoietic phosphatase ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos

Z Kanwal, A Zakrzewska, J den Hertog… - … of Immunology, 2013 - journals.aai.org
… of immune cells (55), but we did not detect enhanced proliferation of myeloid cells during
zebrafish embryonic and larval development. Among the three mutant alleles of Ptpn6 in mice, …

[PDF][PDF] Linking virus discovery to immune responses visualized during zebrafish infections

KM Balla, MC Rice, JA Gagnon, NC Elde - Current Biology, 2020 - cell.com
… discovery with immunology, we genetically modified zebrafish to … We subsequently detected
zebrafish picornavirus in publicly … Zebrafish do not develop an adaptive immune system until …

Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri

R Korbut, F Mehrdana, PW Kania, MH Larsen… - PLoS …, 2016 - journals.plos.org
… In order to detect antigen uptake in zebrafish, a transparent … in the spleen of zebrafish and
developing ellipsoids are … stages of zebrafish have different immunological uptake strategies …

[HTML][HTML] Resident immunity in tissue repair and maintenance: the zebrafish model coming of age

RR Martins, PS Ellis, RB MacDonald… - … and developmental …, 2019 - frontiersin.org
detect and isolate such cells in living tissues. Here we focus on tissue resident or associated
immunity beyond development, in the adult zebrafish… The neuro-immunology field has been …

Host-pathogen interactions made transparent with the zebrafish model

AH Meijer, HP Spaink - Current drug targets, 2011 - ingentaconnect.com
… Schematic overview of the development of the zebrafish … in zebrafish embryos has been
applied to detect innate … of adult zebrafish provides adequate cell numbers for immunological

The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection

LL Chen, J Xie, DD Cao, N Jia, YJ Li, H Sun… - Developmental & …, 2018 - Elsevier
… Accordingly, we detected the temporal expression of aep1 in zebrafish at ten defined
developmental stages from the one-cell stage to the 5-day larvae (Fig. 5a). As shown in real time …

Negative regulator nlrc3-like maintain the balanced innate immune response during mycobacterial infection in zebrafish

L Niu, G Luo, R Liang, C Qiu, J Yang, L Xie… - … in Immunology, 2022 - frontiersin.org
… However, due to the limited antibody resources in zebrafish, it was not possible to detect
not yet developed an adaptive immune system. By studying the embryos of zebrafish lacking …

Zebrafish (Danio rerio) whole kidney assays to measure neutrophil extracellular trap release and degranulation of primary granules

D Palić, CB Andreasen, J Ostojić, RM Tell… - Journal of immunological …, 2007 - Elsevier
detection assays were developed to quantify NET release and degranulation of neutrophil
primary granules from whole zebrafish … potential for use of zebrafish whole kidney assays in …

Rag1−/− Mutant Zebrafish Demonstrate Specific Protection following Bacterial Re-Exposure

C Hohn, L Petrie-Hanson - 2012 - journals.plos.org
… a low level of infection may escape detection. Therefore, we … rag1 −/− mutant zebrafish are
able to develop and maintain … /− mutant zebrafish to examine immunological memory of the …

Detection and signal amplification in zebrafish RNA FISH

G Hauptmann, G Lauter, I Söll - Methods, 2016 - Elsevier
… can be detected. The next progress in zebrafish chromogenic WISH was the development of
protocols … To enable specific immunological detection of each mRNA species, the respective …