Epigenetic modifications at DMRs of imprinting genes in sperm of type 2 diabetic men

M Jazayeri, P Eftekhari-Yazdi, MAS Gilani, M Sharafi… - Zygote, 2022 - cambridge.org
imprinting genes in sperm and semen quality indices in T2DM patients. For this purpose,
sperm … In the next step, methylation of DMRs of the three imprinting genes H19, MEST and …

Abnormal methylation of imprinted genes and cigarette smoking: assessment of their association with the risk of male infertility

H Dong, Y Wang, Z Zou, L Chen, C Shen… - Reproductive …, 2017 - journals.sagepub.com
… in imprinted genes and may result in aberrant spermatogenesis and compromised sperm
In this study, we evaluated the methylation status of 2 imprinted genes in 3 patient populations: …

Ontogeny, conservation and functional significance of maternally inherited DNA methylation at two classes of non-imprinted genes

CE Rutledge, A Thakur, KM O'Neill, RE Irwin… - …, 2014 - journals.biologists.com
imprinted genes and then two transient gDMR classes, one containing genes associated with
testis … (E) Methylation of gDMRs as detected by pyrosequencing in sperm and oocytes. (F) …

Strain-specific defects in testicular development and sperm epigenetic patterns in 5, 10-methylenetetrahydrofolate reductase-deficient mice

D Chan, DW Cushnie, OR Neaga, AK Lawrance… - …, 2010 - academic.oup.com
… results in DNA methylation abnormalities in sperm. The reproductive phenotype associated
sperm numbers and altered testicular histology but showed normal fertility. Imprinted genes

[HTML][HTML] Urine mercury levels correlate with DNA methylation of imprinting gene H19 in the sperm of reproductive-aged men

Z Lu, Y Ma, L Gao, Y Li, Q Li, M Qiang - PloS one, 2018 - journals.plos.org
… Methylation of imprinting genes H19, Meg3 and Peg3 of sperm DNA … between sperm DNA
methylation status of imprinting genes and … of oxidative stress on testicular [8,13]. In particular, …

DNA methylation patterns of spermatozoa and two generations of offspring obtained after murine spermatogonial stem cell transplantation

E Goossens, M De Rycke, P Haentjens… - Human …, 2009 - academic.oup.com
Testicular cell suspensions were transplanted to the testes of … extracted from post-transplantation
spermatozoa, liver, kidney … of DNA methylation in a non-imprinted gene, we included α-…

The paternal methylation imprint of the mouse H19 locus is acquired in the gonocyte stage during foetal testis development

T Ueda, K Abe, A Miura, M Yuzuriha, M Zubair… - Genes to …, 2000 - Wiley Online Library
… be the `imprint' distinguishing the parental alleles of imprinted genes. If such methylation is
to work as the imprinting … between the genomes from sperm and ovulated metaphase II (MII) …

[HTML][HTML] Genetic and epigenetic stability of human spermatogonial stem cells during long-term culture

B Nickkholgh, SC Mizrak, SKM van Daalen… - Fertility and sterility, 2014 - Elsevier
… DNA of human sperm of men with normal sperm counts were … of imprinted genes and sperm
as a fully paternal imprinted cell … testicular cells are shown in both patients for paternally …

Role of Tet1 in erasure of genomic imprinting

S Yamaguchi, L Shen, Y Liu, D Sendler, Y Zhang - Nature, 2013 - nature.com
… RNA-seq reveals extensive dysregulation of imprinted genes in the next generation due to …
sperm of Tet1 knockout mice revealed hypermethylation of DMRs of imprinted genes in sperm

A novel imprinted gene, encoding a RING zinc-finger protein, and overlapping antisense transcript in the Prader-Willi syndrome critical region

MTC Jong, TA Gray, Y Ji, CC Glenn… - … molecular genetics, 1999 - academic.oup.com
… Analyses of adult testis, sperm and fetal oocytes demonstrates a gametic methylation … Our
finding that the 5′-end of the human ZNF127 gene is unmethylated in sperm but is likely to be …