Conserved role of intragenic DNA methylation in regulating alternative promoters
AK Maunakea, RP Nagarajan, M Bilenky, TJ Ballinger… - Nature, 2010 - nature.com
… To determine if intragenic DNA methylation is functional, we first generated high-resolution
methylome maps of the human brain frontal cortex grey matter from two individuals. We …
methylome maps of the human brain frontal cortex grey matter from two individuals. We …
Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer
M Kulis, AC Queirós, R Beekman… - Biochimica et Biophysica …, 2013 - Elsevier
… In particular, it is becoming increasingly clear that DNA methylation in … the potential role of
intragenic DNA methylation in alternative … Furthermore, we summarize how the intragenic DNA …
intragenic DNA methylation in alternative … Furthermore, we summarize how the intragenic DNA …
The regulatory mechanisms of intragenic DNA methylation
SM Lee, WY Choi, J Lee, YJ Kim - Epigenomics, 2015 - Taylor & Francis
… , intragenic DNA methylation was shown to influence transcriptional elongation and alternative
splicing, and abnormal DNA methylation … the importance of intragenic DNA methylation in …
splicing, and abnormal DNA methylation … the importance of intragenic DNA methylation in …
[HTML][HTML] Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research
N Shenker, JM Flanagan - British journal of cancer, 2012 - nature.com
… Of particular interest in breast cancer is the ESR1 gene, which encodes the oestrogen
receptor alpha protein, which we have used to illustrate intragenic DNA methylation from whole-…
receptor alpha protein, which we have used to illustrate intragenic DNA methylation from whole-…
Intragenic DNA methylation prevents spurious transcription initiation
… This work reveals a novel function of intragenic DNA methylation and provides new aspects
that have to be considered when evaluating the roles of SETD2 and DNMT3B in cancer …
that have to be considered when evaluating the roles of SETD2 and DNMT3B in cancer …
[HTML][HTML] Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation
GH Rauscher, JK Kresovich, M Poulin, L Yan, V Macias… - BMC cancer, 2015 - Springer
… to compare our DNA methylation results with those in The Cancer Genome Atlas (TCGA) [14],
one of the most comprehensive public databases on DNA methylation changes in breast …
one of the most comprehensive public databases on DNA methylation changes in breast …
[HTML][HTML] Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks
H Kobayashi, T Sakurai, M Imai, N Takahashi… - PLoS …, 2012 - journals.plos.org
… To elucidate the interaction between intragenic DNA methylation and gene transcription, the
correlation between promoter and gene-body methylation and expression levels for 20,854 …
correlation between promoter and gene-body methylation and expression levels for 20,854 …
The function of intragenic DNA methylation: insights from insect epigenomes
… DNA methylation in insect genomes, we hope to advance an understanding of the function of
intragenic DNA methylation. … We believe the restricted localization of intragenic methylation …
intragenic DNA methylation. … We believe the restricted localization of intragenic methylation …
Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells
MC Lorincz, DR Dickerson, M Schmitt… - Nature structural & …, 2004 - nature.com
… II) was depleted exclusively in the methylated region, as was histone … methylated region
adopts a closed chromatin structure in vivo, we propose that dense intragenic DNA methylation …
adopts a closed chromatin structure in vivo, we propose that dense intragenic DNA methylation …
[HTML][HTML] Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition
… DNA methylation at exons would reduce transcriptional elongation rate and promote exon
inclusion. However, the extent to which DNA methylation … the intragenic DNA methylation is …
inclusion. However, the extent to which DNA methylation … the intragenic DNA methylation is …
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