Synergistic growth inhibition by acyclic retinoid and vitamin K2 in human hepatocellular carcinoma cells

T Kanamori, M Shimizu, M Okuno… - Cancer …, 2007 - Wiley Online Library
… inhibition of growth in human hepatoma HuH7 cells (1, 2) and that this was associated with
… have a synergistic growth-inhibitory effect when combined with VK 2 in leukemia cells, with …

Carnosic acid inhibits proliferation and augments differentiation of human leukemic cells induced by 1, 25-dihydroxyvitamin dsub3 and retinoic acid

M Steiner, I Priel, J Giat, J Levy, Y Sharoni… - Nutrition and …, 2001 - Taylor & Francis
leukemia cells by vitamin E and other antioxidants in combination with low levels of vitamin
… , and Studzinski GP: Synergistic induction of HL60 cell differentiation by ketoconazole and 1-…

New synergistic combinations of differentiation-inducing agents in the treatment of acute promyelocytic leukemia cells

A Amanzadeh, V Molla-Kazemiha, S Samani… - Leukemia Research, 2018 - Elsevier
… of leukemia in adults before the introduction of the vitamin A … of leukemia cells or cell lines
to mature cells in vitro, however, only a few compounds have therapeutic value for leukemia

… of differentiation therapies of acute myeloid leukemia: the search for the molecular basis of patients' variable responses to 1, 25-dihydroxyvitamin D and vitamin D …

A Marchwicka, M Cebrat, P Sampath… - Frontiers in …, 2014 - frontiersin.org
… differentiation of leukemic cells, the idea of treating other AMLs with vitamin D analogs (VDAs…
synergistic induction of differentiation with reduced viability of human myeloid leukemia cell

Activation of vitamin D receptor pathway enhances differentiating capacity in acute myeloid leukemia with isocitrate dehydrogenase mutations

M Sabatier, E Boet, S Zaghdoudi, N Guiraud… - Cancers, 2021 - mdpi.com
… to VD-induced myeloid differentiation and enhanced its synergistic effect with ATRA. This …
/kg 24 h before injection of leukemic cells. Leukemia sample of IDH1 R132H AML patient was …

Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia

C Callens, S Coulon, J Naudin… - Journal of Experimental …, 2010 - rupress.org
… by iron deprivation are also targeted by vitamin D3 (VD), a well … ), indicating a synergistic
interaction. Both combinations … U937), and promyelocytic (NB4) leukemia cell lines used in the …

Pyridoxine induces monocyte-macrophages death as specific treatment of acute myeloid leukemia

W Yang, S Liu, Y Li, Y Wang, Y Deng, W Sun, H Huang… - Cancer Letters, 2020 - Elsevier
… In this study, we confirmed that pyridoxine (vitamin B6) … the treatment of promyelocytic leukemia
by inducing cell differentiation. … The drug resistance of leukemia cells means that a larger …

Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines

T Yokoyama, K Miyazawa… - … journal of oncology, 2005 - spandidos-publications.com
vitamin K2 (menaquinone-4: VK2) has a potent apoptosis-inducing effect in leukemia cell lines
and primary cultured leukemia cells … inhibition of cell growth was not synergistic, this dose …

Enhanced response of acute monocytic leukemia cells to low-dose cytarabine by 1, 25-dihydroxyvitamin D3

H Guo, S Lin, W Ren, Q Lei, Z Chen, L Zhang… - Current Medical …, 2018 - Springer
… Here, firstly, cEioPortal database was used and we found out that vitamin D receptor (VDR) …
Meanwhile, our data suggest that the synergistic effects of 1,25-D3 and low-dose cytarabine …

Antiproliferative effect of a vitamin D3 analog, EB1089, on HL-60 cells by the induction of TGF-β receptor

CW Jung, ES Kim, JG Seol, WH Park, SJ Lee, BK Kim… - Leukemia research, 1999 - Elsevier
… As a positive control for the activity of anti-TGF-β1, we used acute myeloid leukemia cell line
(… Since TGF-β1 had a synergistic effect on proliferation of HL-60 cells when combined with …