… the roles of methionine adenosyltransferases (MATs) in liver cancers with a … carcinoma
(HCC) is the most common primary liver cancer and currently the second leading cause of cancer-…

… ) encode for the essential enzyme methionine adenosyltransferase (MAT), which catalyzes
… and, in the liver, a precursor of glutathione. MAT1A is expressed mostly in the liver, whereas …

… that knockout mice spontaneously develop liver tumors. The induction in MATO mice of
HCC strongly implies that MAT1A helps to prevent liver cancer through its capacity to maintain …

… This review provides an interpretive analysis of recent advances on deregulation of SAM
metabolism in liver injury predisposing to liver cancer and determining HCC prognosis. We …

… (methionine adenosyltransferase 1A) transfection or SAM addition to culture medium.In
mammals the liver… MAT2A up-regulation occurs in liver cirrhosis and HCC of rodents and humans.…

… This review examines the role of methionine adenosyltransferases (MATs) in human
cancer development, with a particular focus on liver cancers in which all three MAT genes are …

… One of these protective genes in liver cancer cells is MAT2B V1. Indeed, silencing V1 but …
survival factor in liver cancer cells. In order to delineate targets of MAT2B in liver cancer cells, …

… Mechanisms of liver cancer development caused by Mat1a … Liver cancer stem cells and
sustained ERK activation Mat1a-KO livers contain increased populations of liver cancer stem …

… role in liver cancer cells and along with MAT2A, can increase the rate of liver cancer cell
growth.… Differential expression of methionine adenosyltransferase genes influences the rate of …

Methionine adenosyltransferase (… (liver-specific) andMAT2A (non-liver-specific). We showed
a switch fromMAT1A to MAT2A expression in human liver cancer, which facilitates cancer …