DNA methylation has a local effect on transcription and histone acetylation

RA Irvine, IG Lin, CL Hsieh - Molecular and cellular biology, 2002 - Taylor & Francis
… Our findings with stable episomes in human cells support the view that DNA methylation
affects transcription locally and that the impact on transcription is negligible when methylation is …

DNA methylation in human epigenomes depends on local topology of CpG sites

C Lövkvist, IB Dodd, K Sneppen… - Nucleic acids …, 2016 - academic.oup.com
… We show that these geometric effects on methylation can be reproduced by a modified
collaborative model, in which the efficiencies of the recruitment-based methylation and …

DNA methylation in Arabidopsis has a genetic basis and shows evidence of local adaptation

MJ Dubin, P Zhang, D Meng, MS Remigereau… - elife, 2015 - elifesciences.org
… Here we investigate DNA methylation variation in Swedish … effects were limited to
transposons, where CHH methylation … that the extensive CHH methylation variation was strongly …

The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood

SM Langevin, EA Houseman, BC Christensen… - Epigenetics, 2011 - Taylor & Francis
… of the potential for local sequence features and genomic context to influence the methylation
state of CpGs will enhance our comprehension of how DNA methylation is regulated under …

Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles

A Martin-Trujillo, N Patel, F Richter, B Jadhav… - PLoS …, 2020 - journals.plos.org
… However, we hypothesized that the effect of genetic variation on DNA methylation might
also occur across wider regions [4,5]. To address this, we followed a similar approach to that …

Genome-wide evaluation of the effect of short tandem repeat variation on local DNA methylation

A Martin-Trujillo, P Garg, N Patel, B Jadhav… - Genome …, 2023 - genome.cshlp.org
… act as independent regulators of local DNA methylation in the … ) and genome-wide DNA
methylation levels derived from whole… major genetic modulator of local DNA methylation profiles. …

Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population

A Al Tuwaijri, V Gagné-Ouellet, AM Madore… - Journal of medical …, 2016 - jmg.bmj.com
DNA methylation has an important role in gene regulation; therefore, we examined DNA
methylation at … Our goal was to determine whether DNA methylation was associated with …

Daily variation in global and local DNA methylation in mouse livers

L Xia, S Ma, Y Zhang, T Wang, M Zhou, Z Wang… - PloS one, 2015 - journals.plos.org
… Previous studies have reported that DNA methylation in human blood shows 24-h variation
[… the DNA methylation state [31]. In this study, we found that global DNA methylation level in …

[HTML][HTML] Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

J Higham, L Kerr, Q Zhang, RM Walker, SE Harris… - Genome Biology, 2022 - Springer
… Here we use human longitudinal DNA methylation profiles to demonstrate a strong effect
of local CpG density on how DNA methylation changes with age (Fig. 6a) and that this can be …

New concepts in DNA methylation

A Jeltsch, RZ Jurkowska - Trends in biochemical sciences, 2014 - cell.com
DNA methylation at each site is determined by the local … Second, we present a modified
stochastic DNA methylation … de novo and the maintenance methylation process at CpG and non-…