DNA demethylation

AP Wolffe, PL Jones, PA Wade - Proceedings of the …, 1999 - National Acad Sciences
… This issue has now been brought into sharper focus by the recent reports of a mammalian
protein with specific demethylase activity for methyl CpG dinucleotides (36), together with a …

[HTML][HTML] DNA methylation and methyl-CpG binding proteins: developmental requirements and function

O Bogdanović, GJC Veenstra - Chromosoma, 2009 - Springer
… are occupied by various proteins, including methyl-CpG binding … of DNA methylation, DNA
methyltransferases, and methyl-CpGDNA methylation makes an essential and versatile …

The methyl-CpG binding domain and the evolving role of DNA methylation in animals

B Hendrich, S Tweedie - TRENDS in Genetics, 2003 - cell.com
DNA methylation-mediated silencing, and to protect against extensive mutation, there was
also a coordinate increase in the number and diversity of methyl-CpG … the methyl-CpG binding …

[PDF][PDF] The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing

Z Lang, M Lei, X Wang, K Tang, D Miki, H Zhang… - Molecular cell, 2015 - cell.com
… limit the spread of DNA methylation by promoting active DNA demethylation. Active DNA
demethylation is also necessary for pruning the DNA methylation landscape of many TEs and is …

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methylCpG binding protein.

J Boyes, A Bird - The EMBO journal, 1992 - embopress.org
… by co-transfection of methylated competitor DNA, suggesting that … methyl-CpG binding
protein. We decided therefore to study further the effect of DNA methylation on transcription of CpG

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

J Boyes, A Bird - Cell, 1991 - cell.com
We have studied the mechanism by which DNA methyiation inhibits transcription both in ceil-free
nuclear extracts and in the living ceil. Repression of transcription in vitro for four …

… of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG …

SS Nair, MW Coolen, C Stirzaker, JZ Song… - Epigenetics, 2011 - Taylor & Francis
… However, DNA methylation patterns are dynamic in nature and vary during development …
The cycle of early embryonic demethylation followed DNA methylation primarily occurs at CpG

[HTML][HTML] The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

F Fuks, PJ Hurd, D Wolf, X Nan, AP Bird… - Journal of Biological …, 2003 - ASBMB
… that MeCP2 facilitates H3 Lys 9 methylation of the H19 gene, a … DNA methylation and
histone methylation and thus reinforce the repressive function of these two distinct methylation

Expression of mRNA for DNA methyltransferases and methyl-CpG–binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions …

Y Saito, Y Kanai, M Sakamoto, H Saito, H Ishii… - Hepatology, 2001 - Elsevier
… level of DNA methyltransferases may contribute to DNA methylation patterns in HCCs,
we analyzed the DNA methylation status on 7 type C CpG islands in the same cohort. DNA

Methyl-CpG-binding domain protein MBD7 is required for active DNA demethylation in Arabidopsis

C Wang, X Dong, D Jin, Y Zhao, S Xie, X Li… - Plant …, 2015 - academic.oup.com
… Although researchers have established that DNA methylation and active demethylation
DNA demethylation and antisilencing of the genomic loci with high densities of DNA methylation