High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines

F Antequera, J Boyes, A Bird - Cell, 1990 - cell.com
… suppressing transcription of CpG islandassociated genes. We found that the presence of
methylCpGs at the a-globin CpG island (Figure 7) and at eight randomly selected CpG islands (…

The methyl-CpG binding domain and the evolving role of DNA methylation in animals

B Hendrich, S Tweedie - TRENDS in Genetics, 2003 - cell.com
… of their methyl-CpG binding domains (MBDs): mammalian MBD3 differs from other methyl-CpG
to phenylalanine, but the MBD solution structure reveals that the hydroxyl group of that …

Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA

K Liu, C Xu, M Lei, A Yang, P Loppnau… - Journal of Biological …, 2018 - ASBMB
… recognized by methyl-CpG–binding protein 2 (MeCP2) to regulate gene expression in
neuron development. However, the molecular mechanism involved in the binding of methyl-CpG–…

Comparative study of methyl-CpG-binding domain proteins

TC Roloff, HH Ropers, UA Nuber - BMC genomics, 2003 - Springer
… BAZ2B has a domain structure similar to BAZ2A/TIP5, both … interaction property of the
methyl-CpG-binding domain of … well as regulated targets of all components. This will help to solve …

Impact of methylation on the physical properties of DNA

A Pérez, CL Castellazzi, F Battistini, K Collinet… - Biophysical journal, 2012 - cell.com
components of this coarse-grained regulatory mechanism include chromatin structure and
epigenetic signatures, where d(CpG… and theoretical study of d(CpG) steps that provides a …

Structural and functional coordination of DNA and histone methylation

X Cheng - Cold Spring Harbor perspectives in biology, 2014 - cshperspectives.cshlp.org
… -dependent methyl transfer to a protein lysine side chain. … Histone arginine methylation is a
component of the “histone code” … unmethylated CpGs was confirmed by a solution structure of …

Engineering a high-affinity methyl-CpG-binding protein

HF Jørgensen, K Adie, P Chaubert… - Nucleic acids …, 2006 - academic.oup.com
CpG sites in double-stranded DNA. By multimerizing the MDB domain of Mbd1, we
engineered a poly-MBD protein that displays methyl-CpG-… Solution structure of the methyl-CpG

Effects of histone acetylation and CpG methylation on the structure of nucleosomes

JY Lee, TH Lee - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2012 - Elsevier
… A large number of components in transcriptional regulatory proteins such as TAF130/250, …
by methyl-CpG binding proteins, our results suggest a novel role for CpG methylation in …

Specific protection of methylated CpGs in mammalian nuclei

F Antequera, D Macleod, AP Bird - Cell, 1989 - cell.com
… If methylation alters chromatin structure directly, we predicted … X by factors bound to
methylCpG, we would expect that … Histone Hl is an abundant component of chromatin, and may …

Molecular structure of (m 5 dC-dG) 3 : the role of the methyl group on 5-methyl cytosine in stabilizing Z-DNA

S Fujii, AHJ Wang, G van der Marel… - Nucleic Acids …, 1982 - academic.oup.com
… The moleoole forms a left-handed Z-DNA helix which is sinilar to the unmethylated Z-DNA
structure. The presence of the methyl … If one looks at the sequence CpG of Z-DNA, the methyl