The methyl-CpG binding transcriptional repressor MeCP2 stably associates with nucleosomal DNA
SP Chandler, D Guschin, N Landsberger… - Biochemistry, 1999 - ACS Publications
… structure on methylated DNA would be to bind repressor proteins that recognize methyl-CpG
present … Histone H1 is an intrinsic component of chromatin in the nuclei of somatic cells. It is …
present … Histone H1 is an intrinsic component of chromatin in the nuclei of somatic cells. It is …
Nonrandom integration of retroviral DNA in vitro: effect of CpG methylation.
Y Kitamura, YM Lee, JM Coffin - Proceedings of the …, 1992 - National Acad Sciences
… is a function of local DNA structure and that selectivity for … PCR products from an integration
reaction with methylated … itself, conferred by some other component of the viral preintegration …
reaction with methylated … itself, conferred by some other component of the viral preintegration …
… activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1
K Shin Voo, DL Carlone, BM Jacobsen… - … and cellular biology, 2000 - Taylor & Francis
… domain, a zinc finger-like structure spanning 50 to 80 amino acids that … structure (Citation1).
Here we describe a new member of the family of CpG binding proteins, denoted human CpG …
Here we describe a new member of the family of CpG binding proteins, denoted human CpG …
Methyl-CpG-binding domain proteins: readers of the epigenome
… The genome is epigenetically regulated at different levels of complexity, from structural …
BAZ2A is a component of the nucleolar remodelling complex NoRC, essential for …
BAZ2A is a component of the nucleolar remodelling complex NoRC, essential for …
Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs
… structural differentiation between CpG islands and bulk DNA. … A 120 kd protein Is a Component
of MeCP Our preliminary … This suggests that a relatively large fraction of the methylCpGs …
of MeCP Our preliminary … This suggests that a relatively large fraction of the methylCpGs …
Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence
JN Scarsdale, HD Webb, GD Ginder… - Nucleic acids …, 2011 - academic.oup.com
… Solution structure of cMBD2 bound to methylated DNA We determined the solution structure
of the methyl … located methylated CpG sequence using multidimensional NMR spectroscopy. …
of the methyl … located methylated CpG sequence using multidimensional NMR spectroscopy. …
Potential role of DNA methylation as a facilitator of target search processes for transcription factors through interplay with methyl-CpG-binding proteins
CA Kemme, R Marquez, RH Luu… - Nucleic acids …, 2017 - academic.oup.com
… CpG methylation moderately changes structural properties of DNA and thereby affects some
… The components we used in these stopped-flow experiments are shown in Figure 2A. To …
… The components we used in these stopped-flow experiments are shown in Figure 2A. To …
Methyl-CpG/MBD2 interaction requires minimum separation and exhibits minimal sequence specificity
B Moreland, K Oman, J Curfman, P Yan… - Biophysical Journal, 2016 - cell.com
… of methylation at CpG dinucleotides in a cell remains an essential component of epigenetic
… at CpG separations of 0 and 1, 2, and 3 bp support our predictions from our structural model …
… at CpG separations of 0 and 1, 2, and 3 bp support our predictions from our structural model …
Complete profiling of methyl-CpG-binding domains for combinations of cytosine modifications at CpG dinucleotides reveals differential read-out in normal and Rett …
BC Buchmuller, B Kosel, D Summerer - Scientific Reports, 2020 - nature.com
… hMBD3, a key component of the Mi-2/… structure-function-relationships reveal markedly
different abilities of the human core family MBDs to discriminate between cognate mC/mC CpG …
different abilities of the human core family MBDs to discriminate between cognate mC/mC CpG …
DNA binding of methyl-CpG-binding protein MeCP2 in human MCF7 cells
C Koch, WH Strätling - Biochemistry, 2004 - ACS Publications
… These apparently contradicting sets of data can be reconciled by assuming that MeCP2
also recognizes sequence and structural information adjacent to methyl-CpGs. We have …
also recognizes sequence and structural information adjacent to methyl-CpGs. We have …