… has been correlated with transcriptional repression and with … interaction surface, termed the
methyl CpG-binding domain or … that are linked to transcriptional repression, namely, MeCP2, …

… that can cleave CpG [5,6]. A model that could accommodate both gene repression and altered
… gene, leading to an altered chromatin structure, which would in turn deny access to the …

… of CpG methylation. I find that the repression is a graded but exponential function of the CpG
methylation density such that low levels of methylation yield a 67 to 90%o inhibition of gene …

… four affected the methyl-CpG-binding domain … transcriptional repression of the SV40
enhancer/promoter. In contrast, mutation of segments D and E only weakly relieved trans-repressing …

… transcriptional repressor mSin3A and histone deacetylases 13,14,15,16,17,18,19 . Transcriptional
repression in … repression mechanism. The data suggest that two global mechanisms of …

… -1 in transcriptional repression involved promoters that are rich in methyl-CpG. The known
… to a lower density of 1 methyl-CpG per 62 bp (24 methyl CpGs over 1.5 kb) by using the …

… of transcriptional repression by the TRD of MBD1, we have recently found that a transcriptional
… associated factor (MCAF), binds the TRD of MBD1 to form the repressive complex ( …

… gene repression and altered chromatin would be that methyl-CpG binding proteins, or MeCPs,
bind to a methylated gene … the transcription machinery (Lewis and Bird, 1991). Binding of …

… transcriptional repressor, transcriptional profiling of RNAs from mice lacking MeCP2 did not
reveal significant gene … not simply function as a global repressor. Changes in expression of a …

… CpG methylation in vertebrates is important for gene … protein factors that contain shared
methyl-CpG-binding domains (… methylation-dependent transcriptional repressor MBD1 by multi-…