… on mammalian organisms, where epigenetic DNA methylation targets … Citation 3 Mice
lacking the DNA methylating enzymes … that DNA methylation is essential in mammals.Citation 4 …

… binding for methylated or unmethylated DNA, motifs with CpGs in the center were not bound
when methylated and motifs with CpGs in the flank were bound when methylated [45]. This …

… methylation-dependent transcription factor–DNA interactions are important stepping stones
towards a mechanistic understanding of methylation-… with methylated CpG sites in mammals, …

… Thus, even though there is clear evidence that the binding of transcription factors such as
myc to their cognate sites can be blocked by methylation (39), detailed experiments on the …

… preferential activity for hemi-methylated DNA over unmethylated DNA. It seems likely … DNA.
For this they are called “de novo” methyltransferases. After DNA replication, methylated DNA …

… In this review, we focus on regulation of methylation patterns at mammalian genomic elements
such as promoters and enhancers; for a summary of the regulation of large scale changes …

… In mammals, the methylation of CpG … transcription factors from binding to regions of DNA
called promoters. This can occur directly if methylation disrupts interactions between the DNA …

… of transcription factor binding over DNA methylation in this … unmethylated state, even
without measurable transcription … of transcription factor binding and DNA methylation confirms …

… Although we currently still lack concrete evidence, it is plausible that a major function of
mammalian DNA methylation is transitioning between, rather than maintaining cellular states. …

… The recent advances in the field had a significant impact on our understanding of the role
of DNA methylation in mammals, the enzymatic machineries involved in its regulation and its …