Active repression of methylated genes by the chromosomal protein MBD1

HH Ng, P Jeppesen, A Bird - Molecular and cellular biology, 2000 - Taylor & Francis
… A previous study showed that MBD1 is able to repress transcription of a methylated gene in
… We show that MBD1 can actively repress methylated genes in vivo via a powerful repression

DNA methylation: the nuts and bolts of repression

TB Miranda, PA Jones - Journal of cellular physiology, 2007 - Wiley Online Library
… if DNA methylation really plays a … methylation in the silencing of germline specific genes
(Weber et al., 2007). By looking at global DNA methylation, this study found a subset of genes

How does DNA methylation repress transcription?

SU Kass, D Pruss, AP Wolffe - Trends in Genetics, 1997 - cell.com
… until successive cell divisions eventually unravel the repressive chromatin structure.
Although we focus on molecular mechanisms that might influence DNA methylation and gene

DNA methylation and silencing of gene expression

J Newell-Price, AJL Clark, P King - Trends in Endocrinology & Metabolism, 2000 - cell.com
… These data underscored the importance of MeCP2 for development and in mediating some
of the repressive effects of methylation, but suggested that other MBDs are also likely to play …

Role of DNA methylation in stable gene repression

L Lande-Diner, J Zhang, I Ben-Porath… - Journal of Biological …, 2007 - ASBMB
… DNA methylation on both gene expression and chromatin structure. Our results confirm that
the underlying methylation … that many methylated genes are subject to additional repression

DNA methylation directs a time-dependent repression of transcription initiation

SU Kass, N Landsberger, AP Wolffe - Current biology, 1997 - cell.com
… ) thymidine kinase (tk) gene after injection into rodent cells … methylation-dependent repression
of gene activity. Here, we examine the mechanism of methylation-dependent HSV tk gene

Dependence of transcriptional repression on CpG methylation density

CL Hsieh - Molecular and cellular biology, 1994 - Am Soc Microbiol
repression is a graded but exponential function of the CpG methylation density such that low
levels of methylation … CpG methylation is also an important regulator of gene expression in …

Brain feminization requires active repression of masculinization via DNA methylation

BM Nugent, CL Wright, AC Shetty, GE Hodes… - Nature …, 2015 - nature.com
… The marked decrease in fully methylated CpGs following … fully methylated CpGs in the female
POA serve to repress gene … subset of genes to be methylation-dependent gene candidates …

The role of epigenetic transcription repression and DNA methyltransferases in cancer

FI Daniel, K Cherubini, LS Yurgel, MAZ de Figueiredo… - Cancer, 2011 - Wiley Online Library
… of lysine 9 in the core histone H3 is associated with silenced genes,70 whereas methylation
of lysine 4 in histone H3 is a feature of active genes.22 DNA methylation and histone …

[PDF][PDF] Mechanisms of transcriptional repression by histone lysine methylation

P Hublitz, M Albert, A Hfmpeters… - International Journal of …, 2009 - researchgate.net
methylation mediated repression, and describe the functional interplay with activating H3K4
methylation. … outcomes from stable repression to highly dynamic regulated genes, strongly …