Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
PL Jones, GJC Veenstra, PA Wade, D Vermaak… - Nature …, 1998 - nature.com
… MeCP2 is a methylation-specific transcriptional repressor that is … Transcription from the
methylated hsp70 promoter was … active role in repressing transcription on methylated DNA. This …
methylated hsp70 promoter was … active role in repressing transcription on methylated DNA. This …
Active repression of methylated genes by the chromosomal protein MBD1
HH Ng, P Jeppesen, A Bird - Molecular and cellular biology, 2000 - Taylor & Francis
… transcriptional repression domain (TRD) at the C terminus of MBD1 that can actively repress
transcription at a … This is most apparent at densely methylated CpG island promoters on the …
transcription at a … This is most apparent at densely methylated CpG island promoters on the …
DNA methylation and silencing of gene expression
J Newell-Price, AJL Clark, P King - Trends in Endocrinology & Metabolism, 2000 - cell.com
… this transcriptional repression is mediated, with particular emphasis on the role of binding
proteins that preferentially recognize methylated … -specific ‘pituitary’ promoter of the somatically …
proteins that preferentially recognize methylated … -specific ‘pituitary’ promoter of the somatically …
DNA methylation in transcriptional repression of two differentially expressed X-linked genes, GPC3 and SYBL1
R Huber, RS Hansen, M Strazzullo… - Proceedings of the …, 1999 - National Acad Sciences
… in vitro methylation of multiple CpG dinucleotides in the promoter … methylation is sufficient
for transcriptional repression. CpG-island methylation also is correlated with in vivo repression …
for transcriptional repression. CpG-island methylation also is correlated with in vivo repression …
Role of protein methylation in regulation of transcription
DY Lee, C Teyssier, BD Strahl, MR Stallcup - Endocrine reviews, 2005 - academic.oup.com
… -4 methylation with gene activation, there are some cases in which this modification is
implicated in gene repression, … It is possible that methylation of H3 Lys-36 in promoter regions of …
implicated in gene repression, … It is possible that methylation of H3 Lys-36 in promoter regions of …
Methylated DNA-binding domain 1 and methylpurine–DNA glycosylase link transcriptional repression and DNA repair in chromatin
S Watanabe, T Ichimura, N Fujita… - Proceedings of the …, 2003 - National Acad Sciences
… found that MBD1 was dissociated from the methylated gene promoter under the conditions
of MMS … We discuss a mechanistic link between DNA repair, gene repression, and chromatin …
of MMS … We discuss a mechanistic link between DNA repair, gene repression, and chromatin …
Hypoxia and chromatin: a focus on transcriptional repression mechanisms
… methylation changes, further analysis on how histone methylation contributes to the
transcriptional repression … that hypoxia increased DNA methylation across promoters in a manner …
transcriptional repression … that hypoxia increased DNA methylation across promoters in a manner …
… induction and de novo methylation: implications for a histone deacetylase-independent, methylation density-dependent mechanism of transcriptional repression
MC Lorincz, D Schübeler, SC Goeke… - … and cellular biology, 2000 - Taylor & Francis
… Analyses of histone acetylation in in vitro-methylated … de novo DNA methylation, transcriptional
repression, and histone … promoter region and the hGFPgene are de novo methylated …
repression, and histone … promoter region and the hGFPgene are de novo methylated …
Inhibition of promoter activity by methylation: possible involvement of protein mediators.
A Levine, GL Cantoni, A Razin - Proceedings of the …, 1991 - National Acad Sciences
… promoter activity we have methylated in vitro the promoters of the mouse metallothionein I
gene and the herpes simplex virus thymidine kinase gene… that the lack of repression in F9 cells …
gene and the herpes simplex virus thymidine kinase gene… that the lack of repression in F9 cells …
DNA hypermethylation accompanied by transcriptional repression in follicular lymphoma
LB Bennett, JL Schnabel, JM Kelchen… - Genes …, 2009 - Wiley Online Library
… CpG Island Amplification with Microarrays to study CpG Island DNA methylation in FL, we …
(c) Bisulfite genomic sequencing to determine the methylation status of CpGs in promoter …
(c) Bisulfite genomic sequencing to determine the methylation status of CpGs in promoter …