Dependence of transcriptional repression on CpG methylation density
CL Hsieh - Molecular and cellular biology, 1994 - Am Soc Microbiol
… of CpG methylation. I find that the repression is a graded but exponential function of the
CpG methylation density such that low levels of methylation yield a 67 to 90%o inhibition of …
CpG methylation density such that low levels of methylation yield a 67 to 90%o inhibition of …
Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl‐CpG binding protein.
J Boyes, A Bird - The EMBO journal, 1992 - embopress.org
… The experiments implicating MeCP-1 in transcriptional repression involved promoters
that are rich in methyl-CpG. The known preference of MeCP-1 for multiple methyl-CpGs on a …
that are rich in methyl-CpG. The known preference of MeCP-1 for multiple methyl-CpGs on a …
[PDF][PDF] Mechanisms of transcriptional repression by histone lysine methylation
P Hublitz, M Albert, A Hfmpeters… - International Journal of …, 2009 - ijdb.ehu.es
… We summarize recent data that indicate a close relationship between GC density of promoter
sequences, transcription factor binding and the antagonizing activities of distinct epigenetic …
sequences, transcription factor binding and the antagonizing activities of distinct epigenetic …
… induction and de novo methylation: implications for a histone deacetylase-independent, methylation density-dependent mechanism of transcriptional repression
MC Lorincz, D Schübeler, SC Goeke… - … and cellular biology, 2000 - Taylor & Francis
… in methylation-mediated repression. Analyses of histone acetylation in in vitro-methylated …
among de novo DNA methylation, transcriptional repression, and histone acetylation state. To …
among de novo DNA methylation, transcriptional repression, and histone acetylation state. To …
DNA methylation in the gene body influences MeCP2-mediated gene repression
B Kinde, DY Wu, ME Greenberg… - Proceedings of the …, 2016 - National Acad Sciences
… the degree of gene repression by MeCP2 is proportional to the total number of methylated
cytosine … Previously we have observed that both gene-body mCA density and gene length are …
cytosine … Previously we have observed that both gene-body mCA density and gene length are …
How does DNA methylation repress transcription?
… DNA that can be explained by methylation-specific re… Transcriptional repression is strongly
related to the density of … at low densities of methyl-CpG and repression at higher densities. …
related to the density of … at low densities of methyl-CpG and repression at higher densities. …
[HTML][HTML] Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers
… increasing density of methylation, but whether density itself … have higher levels of gene
promoter methylation compared with HPV-… of transcriptional repression from DNA methylation at …
promoter methylation compared with HPV-… of transcriptional repression from DNA methylation at …
Methyl CpG‐binding proteins and transcriptional repression
PA Wade - Bioessays, 2001 - Wiley Online Library
… mechanisms that might lead to transcriptional repression at methylated loci. Certain … for
methylation density, of full-length MeCP2 from any species. Transcriptional repression mediated …
methylation density, of full-length MeCP2 from any species. Transcriptional repression mediated …
DNA methylome in human CD4+ T cells identifies transcriptionally repressive and non-repressive methylation peaks
… CpG island density in promoter sequences predict transcriptional permissiveness of DNA …
transcriptionally repressive from permissive DNA methylation peaks in promoter gene …
transcriptionally repressive from permissive DNA methylation peaks in promoter gene …
[HTML][HTML] MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
… MeCP2 repress transcription in vitro from methylated promoters but do not … Repression is
nonlinearly dependent on the local density of methylation, becoming significant at the density …
nonlinearly dependent on the local density of methylation, becoming significant at the density …
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