Multi‐omic integration of DNA methylation and gene expression data reveals molecular vulnerabilities in glioblastoma

P Santamarina‐Ojeda, JR Tejedor, RF Pérez… - Molecular …, 2023 - Wiley Online Library
… In this study, we have performed genome-wide transcriptomic and DNA methylation … -specific
vulnerabilities within GBM IDHWT tumours and identifying potential molecular pathways …

Making it or breaking it: DNA methylation and genome integrity

A Sriraman, TK Debnath, B Xhemalce… - Essays in …, 2020 - portlandpress.com
DNA methylation and DNA repair processes, although the molecular function of DNA
methylation in DNA … that could provide genetic vulnerabilities to these compounds can offer …

Molecular mechanisms underlying the link between diet and DNA methylation

FZ Kadayifci, S Zheng, YX Pan - International journal of molecular …, 2018 - mdpi.com
… the effects of nutrition on DNA methylation pathways, but to our … in DNA methylation and
demethylation. We also aim to go through all of the possible nutrient and DNA methylation

Methyl nutrients, DNA methylation, and cardiovascular disease

MB Glier, TJ Green, AM Devlin - Molecular nutrition & food …, 2014 - Wiley Online Library
… Furthermore, epigenetic regulation of gene expression and DNA methylation profiles are
tissue and cell specific so the vulnerability will be cell and tissue specific and dependent on the …

Exploiting epigenetic vulnerabilities for cancer therapeutics

B Mair, S Kubicek, SMB Nijman - Trends in pharmacological sciences, 2014 - cell.com
DNA methylation also affect the cell mutation rate, for instance, through higher rates of
spontaneous deamination at methylated … Not only DNA methylation but also histone methylation, …

The impact of metabolism on DNA methylation

CL Ulrey, L Liu, LG Andrews… - Human molecular …, 2005 - academic.oup.com
DNA methylation is critical for developmental changes in gene regulation, the classic model
being promoter methylation in … for the defect are vulnerable to hyperhomocysteinemia when …

DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker

J Tost - Molecular biotechnology, 2010 - Springer
DNA methylation patterns are susceptible to change in response to environmental stimuli …
to be most vulnerable during early in utero development. Aberrant DNA methylation changes …

Minireview: epigenomic plasticity and vulnerability to EDC exposures

CL Walker - Molecular Endocrinology, 2016 - academic.oup.com
… Both DNA methylation and histone modifications have been shown to be vulnerable to
disruption … into epigenomic plasticity that is vulnerable to disruption by environmental exposures. …

DNA methylation-based predictors of health: applications and statistical considerations

PD Yousefi, M Suderman, R Langdon… - Nature Reviews …, 2022 - nature.com
… to the development of DNA methylation-based predictors across a … the progress of existing
DNA methylation-based predictors, … capacity for functional molecular interpretation. However, …

Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation

MM Mitchener, TW Muir - Molecular cell, 2022 - cell.com
… fidelity down unique cell lineages is at the core of molecular epigenetics research. One key
component of this elaborate choreography is the covalent modification of DNA and histones ( …