… of the DNA methylation mark in vivo that could not be fully evaluated for Dnmt1 null mutant
mice and … Based on our finding that DNA methylation marks are essential for proper DNMT1 …

… germ line and early embryo. Some CpG sites are methylated in sperm DNA and unmodified
in … of the biochemical mechanisms and role of DNA methylation in embryonic development. …

… methylation has come from the study of mouse embryonic stem (ES) cells, which have
pluripotent … In cell lines, the marked effect on DNA methylation levels is a consequence of their …

… the presence of a germline methylation mark 47 . The graphs … between embryonic stem
cells 37 or that DNA methylation is … to EpiSCs, DNA methylation in embryonic stem cells does …

… Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and
germ cell lineages during mouse embryo development. Development 99, 371–382. Ng, HH, …

… genome and is essential for embryonic viability. With several of … of the mechanisms by which
DNA methylation is targeted to … Dicer-deficient mouse embryonic stem cells are defective in …

… the embryonic epigenetic reprogramming of DNA methylation … procedures affect development
and DNA methylation marks. … of the mouse embryonic epigenetic reprogramming of DNA …

… is highly dynamic during mammalian embryogenesis. It is … -scale DNA methylation maps
in mouse gametes and from … to lead to equivalently marked demethylation on the basis of …

… the role of DNA methylation at tissue-specific enhancers and suggest that epigenetic memory
of embryonic … DNA methylation is a heritable epigenetic mark that is critical for mammalian …

… This comparatively static landscape is in marked contrast with the events of fertilization, …
The isolated ICM was then plated on a layer of gamma-irradiated mouse embryonic fibroblasts (…