… particular, high-risk myelodysplastic syndromes (MDS) and secondary leukemias (SL) show
a high prevalence of tumor-suppressor gene hypermethylation. The use of irreversible DNA …

… of action of these agents in MDS and show that demethylation … though DNA methylation has
been studied extensively in MDS… the complexity of epigenetic dysregulation in this disease. …

… This review focuses on DNA methylation changes as potential biomarkers for … and
myelodysplastic syndrome. Here, we report that distinct changes in DNA methylation may alter gene …

… myelodysplastic syndromes (MDS). We hypothesized that MDS subtypes defined by DNA
methylation (DNAm) patterns could enhance our understanding of MDS disease biology and …

… Unexpectedly, the methylation level of the LINE-1 sequences demonstrated a distinct and
… DNA methylation in MDS patients compared with the control group. This hypermethylation …

… on the treatment paradigm of myelodysplastic syndromes (MDS), … value in the treatment of
MDS did not become evident until 30 … to be approved by the US FDA for the treatment of MDS. …

… DNA methylation at enhancers is disrupted in AML and MDS and mainly hyper-methylation
at … In this review, we have assembled recent data regarding DNA methylation and enhancers’ …

… In particular, high-risk myelodysplastic syndromes (MDS) and … gene hypermethylation. The
progression of chronic myeloproliferative diseases and of myelodysplastic syndromes, as well …

… ordered DNA methylation and histone modification programs. Aberrant differentiation … MDS
can often be traced to abnormal DNA methylation (both gains and losses of DNA methylation …

… that global DNA methylation predicts overall survival in myelodysplastic syndromes. … In
this study, we examined the prognostic significance of global DNA methylation and …