… pathophysiology of MDS and AML, unraveling the DNA methylation profiles … disease. The
aim of this work was to decipher the DNA methylation specificities of primary BM MSCs of MDS …

… , such as myelodysplastic syndromes (MDSs), are responsive to DNA … hypermethylation
in such tumors, we compared the distribution of DNA methylation of 14 000 promoters in MDS …

Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder. Several … and serum
of patients with MDS can be used to detect genetic/epigenetic abnormalities. The plasma …

… Previously, we determined the genome-wide DNA methylation alterations during MDS …
-wide DNA hypermethylation changes were a common phenomenon during MDS progression (10…

… Two nucleoside inhibitors of DNA methylation, azacitidine and decitabine, are now standard
of care for the treatment of the myelodysplastic syndrome, a deadly form of leukemia. These …

… There is now genetic evidence that DNA methylation is important in MDS, because … methylation
are somatically mutated in MDS genomes (DNMT3A, TET2, and IDH1/IDH2). Methylation …

… in the pathogenesis of myelodysplastic syndrome (MDS). Southern blotting analysis showed
no gross genetic alterations in either of these genes. However, hypermethylation of the 5′ …

… levels of the DNA methylation and demethylation machinery components in pediatric patients
with MDS. DNMT1, DNMT3A, and DNMT3B were overexpressed in pediatric MDS when …

… To control the specificity of the MSP reactions, we used leukocyte DNA methylated in
vitro by the action of Sss1 CpG Methylase enzyme (New England Biolabs), according to the …

… for DNA methylation detection in MDS … of DNA methylation in BM and PB samples of MDS
patients. We observed the higher correlation rates in P15 and TRAIL DcR1 gene methylation. …