… methylation of multiple CpG islands has been described in acute myeloid leukemia (AML), …
whether they reflect specific methylation defects in a subset of cases. To study this issue, the …

… In combination with CpG island microarrays, the technique was used to identify >… methylated
CpG islands in three myeloid leukemia cell lines. Interestingly, within all hypermethylation …

… Aberrant DNA methylation patterns are a characteristic feature of … myeloid malignancies
such as acute myeloid leukemia (AML). The mechanisms behind aberrant DNA methylation …

… In this review, we summarize the current knowledge of DNA methylation in normal … of
DNA methylation and the current therapeutic strategies of targeting DNA methylation in …

… DNA, pre- and post-decitabine patterns of DNA methylation could provide an insight into
underlying mechanisms. However, changes in promoter CpG methylation are … DNA methylation …

… We hypothesized that DNA methylation distributes into specific patterns in cancer cells, …
We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia …

… leukemia subgroups based on distinct DNA methylation patterns. Furthermore, we defined a
methylation… Here, we report the first large-scale methylation-based outcome predictor in AML…

… Aberrant promoter DNA methylation has been shown to play a role in acute myeloid leukemia
(… signatures with defined genomic rearrangements in acute myeloid leukemia are required. …

… DNA methylation changes in myeloid leukemia cell lines and in patients. Our results show
differential demethylation responses in myeloid leukemia … genomic DNA methylation patterns …

… leukemia from the same cohort of patients. We used bisulfite genomic sequencing to characterize
the methylation pattern of the CpG islands … patients with acute myeloid leukaemia (AML…