… This article discusses the role of different niche cells and … role for BMSCs in myeloid
malignancies arose from studies … in hematopoietic cells of patients with myeloid malignancies and …

… malignant hematopoietic stem cells in myeloid malignancies, such as myeloproliferative
neoplasms, myelodysplastic syndromes, and acute myeloid … dynamic cellular microenvironment …

… This population can be expanded dramatically in inflammation and some myeloid
neoplasms, indicating a skewed maturational progression, and should not be mistaken for an …

… in hematopoietic progenitors. Recent advances in our understanding of the genetic basis …
myeloid malignancies have provided important insights into the pathogenesis of acute myeloid …

… Myeloid malignancies are clonal diseases of hematopoietic stem or progenitor cells.
They result from genetic and epigenetic alterations that perturb key processes such as self-renewal, …

… of myeloid malignancies, we analyzed LSK and LK cell population in the BM of 6- to 7 week-old
Tet2 −/− mice. The proportion of LSK cells … without hematologic malignancies compared …

… of recognizable heritable hematopoietic malignancy syndromes … with inherited hematopoietic
malignancies continue to be … of having a hereditary myeloid malignancy syndrome. Finally, …

… that are central to the pathogenesis of myeloid malignancies have direct epigenetic
functions in addition to their canonical roles in promoting haematopoietic cell proliferation. …

… Studies using ASXL1-depleted human hematopoietic cells … impaired hematopoiesis and
accelerates myeloid malignancies … On the other hand, ASXL1 mutations in myeloid neoplasms …

… Five major subgroups of myeloid neoplasms are recognized based mainly on their … neoplasms
(MPNs) which are comprised primarily of mature cells with effective proliferation; myeloid (…